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MetExome 360 (Whole Exome & Mitochondrial Genome Sequencing)**
₹ 25000
MetExome 360 (Whole Exome & Mitochondrial Genome Sequencing)
₹ 25000 ₹ 25000

MetExome 360 (Whole Exome & Mitochondrial Genome Sequencing)

Sample Type 51+ booked in last 3 days
Precaution
Fasting
Yes
Precaution
Report
Within 4 Weeks

MetExome 360 (Whole Exome & Mitochondrial Genome Sequencing)** Price

₹ 25000

Brief Details

Preparation
No special preparation required
Also Known As
MetExome 360, Whole Exome & Mitochondrial Genome Sequencing, Whole Exome Panel
Fasting
Not required
Reporting Time
After 4 weeks
Purpose
Comprehensive genetic test sequencing all protein-coding genes & mitochondrial genes to aid in diagnosing genetic disorders and rare diseases

What is a Whole Exome Sequencing Test? 

A whole exome sequencing genetic test is an advanced genetic examination that reads and analyses all the protein-coding regions of your DNA. Your complete set of DNA is called the genome, and the exome represents the small but crucial part (about 1-2%) that contains instructions for making proteins. Proteins are the essential building blocks that perform most functions in your body's cells. 

This DNA sequencing test helps identify specific genetic changes (mutations or variants) that may be the root cause of rare diseases, complex medical conditions, or developmental disorders that have been difficult to diagnose through other tests. 

What does the Whole Exome Sequencing Test measure?  

The whole exome sequencing test systematically examines your genetic code to find the cause of unexplained health conditions: 

  • Reads your genetic code: Deciphers the exact sequence of your exome, which contains blueprints for proteins 
  • Identifies genetic variations: Compares your exome sequence to standard references to find differences called genetic variants or mutations 
  • Analyses potential impact: Genetic experts determine if variants are harmless variations or harmful changes that could disrupt protein function 
  • Provides potential diagnosis: Links pathogenic variants to your symptoms to offer a precise genetic diagnosis for previously unexplained conditions 

Whole Exome Sequencing Test: Who Needs It and Why It's Done 

What Symptoms May Call for a Whole Exome Sequencing Test? 

Doctors may recommend the whole exome sequencing genetic test when you have complex symptoms that standard tests cannot explain. Common signs that may indicate the need for testing include: 

  • Developmental delay or intellectual disability 
  • Multiple birth defects or unusual facial features 
  • Problems affecting multiple organ systems simultaneously 
  • Severe muscle weakness or movement disorders 
  • Progressive loss of previously acquired skills 
  • Suspected genetic disorder where other specific genetic tests have been negative 

Who should get a Whole Exome Sequencing Test? 

The whole exome sequencing genetic test is specifically recommended for certain individuals rather than routine screening: 

  • Patients with complex, undiagnosed symptoms: Children and adults with suspected rare genetic disorders where doctors cannot identify a cause 
  • Individuals with family history: People who have a family history of genetic heath conditions but standard tests have not identified the specific familial genetic disorders 
  • Foetuses with abnormalities: In prenatal cases where ultrasound shows multiple abnormalities in the developing baby 

Why is a Whole Exome Sequencing Test done? 

A whole exome sequencing test provides a specific diagnosis for complex medical puzzles, ending years of uncertainty for families and guiding future medical management and treatment decisions. 

Importance of a Whole Exome Sequencing Test 

The whole exome sequencing genetic test is clinically vital because it can provide definitive answers when all other medical investigations have failed. Its significance lies in pinpointing the exact genetic root of health problems. 

  • Ending diagnostic uncertainty: For many families, the biggest benefit is simply getting a name for their condition, relieving emotional stress and providing clarity.  
  • Informing treatment approaches: While cures may not always be available, specific diagnosis helps doctors manage conditions better, recommend appropriate therapies, and anticipate future health concerns.  
  • Supporting family planning: A diagnosis allows families to understand inheritance patterns, crucial for genetic counselling and making informed decisions about future pregnancies.  
  • Connecting with support: Confirmed diagnosis helps families connect with support groups and communities affected by the same rare hereditary diseases. 

Whole Exome Sequencing Test Booking & Reports – Metropolis Healthcare India 

How to Book a Whole Exome Sequencing Test? 

  1. Simple Online Booking 
    Booking can be done through the Metropolis Healthcare app or website. Select Whole Exome Sequencing Test, choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab. 
     
  2. Safe Home Sample Collection 
    Our trained phlebotomists ensure timely collection of your sample while strictly following all safety and hygiene protocols. 
     
  3. Sample Tracking Updates 
    Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website.
     
  4. Accurate Laboratory Testing 
    Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 
     
  5. Quick & Easy Reports 
    Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is home sample collection for Whole Exome Sequencing Test available near you?  

Yes, home blood sample collection is available for the whole exome sequencing genetic test. Our trained phlebotomists visit your home at your preferred time, ensuring safe and hygienic sample collection following strict protocols. This service eliminates the need for hospital visits, making advanced DNA sequencing accessible from the comfort of your home. With Metropolis Healthcare's extensive network of over 10,000 touchpoints across India, we're committed to providing reliable, accurate genetic testing that fits your schedule and location preferences. 

How Long Does It Take to Get a Whole Exome Sequencing Test Report?  

Reports are usually available after 4 weeks once the sample reaches the pathology lab. 

Note: Reporting time may vary depending on your location. 

Where can I see or get Whole Exome Sequencing Test results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare app to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting Whole Exome Sequencing Test Results 

What Your Whole Exome Sequencing Test Results May Indicate 

The following table explains how multiple genetic variants are classified in your whole exome sequencing report: 

Variant Classification 

Category 

Clinical Significance 

Class 1 

Pathogenic 

Disease-causing variant confirmed to be responsible for the condition 

Class 2 

Likely Pathogenic 

Very likely to be disease-causing but requires additional confirmation 

Class 3 

Variant of Uncertain Significance (VUS) 

Unclear clinical significance, requires further research and monitoring 

Class 4 

Likely Benign 

Probably harmless variation with minimal health impact 

Class 5 

Benign 

Confirmed harmless variation with no health consequences 

Conditions that May Affect Whole Exome Sequencing Test Accuracy 

Several technical and sample-related factors can influence your whole exome sequencing test results: 

  • Sample quality issues: Haemolysed, lipemic, icteric, or clotted blood samples may affect DNA quality and sequencing accuracy 
  • Insufficient sample volume: Inadequate blood quantity (less than 3-5ml) may compromise test reliability 
  • Storage conditions: Improper sample storage temperature or prolonged storage beyond recommended timeframes can degrade DNA 
  • Technical limitations: Homopolymer regions, GC-rich areas, and pseudogenes may have decreased sequencing coverage 
  • Genetic complexity: Large deletions, duplications, triplet repeat expansions, and chromosomal rearrangements are not reliably detected 

How is a Whole Exome Sequencing Test Done? 

The whole exome sequencing process involves several sophisticated laboratory steps to analyse your genetic information: 

  • A healthcare professional draws 3-5ml of blood from a vein in your arm using an EDTA tube 
  • Genomic DNA is isolated from your blood sample in the laboratory 
  • Sophisticated bioinformatics pipelines identify and classify genetic variants using multiple databases 
  • Expert geneticists analyse variants according to international guidelines (ACMG recommendations) 
  • A comprehensive report detailing findings and clinical significance is prepared by qualified pathologists 

How Should You Prepare for a Whole Exome Sequencing Test? 

Preparing for your whole exome sequencing test is straightforward with minimal requirements: 

  • You can eat and drink normally before the test as food intake doesn't affect DNA analysis 
  • Take all your regular medications as prescribed unless specifically advised otherwise by your doctor 
  • Maintain normal fluid intake to make blood collection easier for the phlebotomist 
  • Provide detailed medical history and genetic family history to help with accurate interpretation 
  • Wear clothing with sleeves that can be easily rolled up for blood collection 

Diseases that a Whole Exome Sequencing Test Can Help Detect 

This comprehensive genetic test can help identify the underlying cause of various complex health risks: 

  • Neurodevelopmental disorders: Intellectual disability, autism spectrum disorders, and developmental delays 
  • Neurological conditions: Epilepsy, neurodegenerative diseases, and movement disorders 
  • Metabolic disorders: Inherited enzyme deficiencies and metabolic pathway disruptions 
  • Congenital malformations: Birth defects affecting multiple organ systems 
  • Muscle disorders: Muscular dystrophies, myopathies, and neuromuscular conditions 
  • Cardiac conditions: Inherited cardiomyopathies and congenital heart diseases 
  • Haematological disorders: Blood disorders like haemolytic anaemias and clotting disorders 
  • Immunodeficiency syndromes: Primary immune system defects and recurrent infections 

Whole Exome Sequencing Test/Packages that You Can Book With Metropolis Healthcare 

Metropolis Healthcare offers comprehensive genetic testing options to support your diagnostic journey: 

Test/Package Name 

Purpose/Highlights 

Genetics Counselling Test 

Professional guidance for understanding genetic test results and family planning decisions 

Clinical Exome Panel 

Targeted genetic analysis focusing on clinically relevant genes for specific conditions 

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

Regular exercise, a balanced diet, avoiding smoking, maintaining a healthy weight, and managing stress all help reduce heart disease risk.

Common signs include irritability, trouble sleeping, headaches, difficulty concentrating, and muscle tension.

Book a Home Visit Now

Book any blood test or health checkup and get tested at the comfort of your home.

Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Choose precision On time, every time!

Precision
  • 98% on time collections with a 60 minutes promise
  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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About Us

Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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