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Neurodegeneration with brain iron accumulation gene panel
₹ 19400
Neurodegeneration with Brain Iron Accumulation Gene Panel
₹ 19400 ₹ 19400

Neurodegeneration with Brain Iron Accumulation Gene Panel

Sample Type 51+ booked in last 3 days
Precaution
Sample Type
Swab
Precaution
Fasting
Yes
Precaution
Report
Within 4 Weeks

Neurodegeneration with brain iron accumulation gene panel Price

₹ 19400

Brief Details

Preparation
No special preparation required
Also Known As
Neurodegeneration with brain iron accumulation Gene Panel by NGS
Fasting
Fasting not required
Reporting Time
After 4 weeks
Purpose
To identify genetic causes of neurodegeneration with brain iron accumulation and support diagnosis, prognosis, and family counselling

What is the Neurodegeneration with Brain Iron Accumulation Gene Panel?

The Neurodegeneration with Brain Iron Accumulation Gene Panel is a genetic blood test used to identify inherited conditions in which excess iron accumulates in specific areas of the brain. These rare disorders can lead to progressive movement problems, muscle stiffness, cognitive decline, and neurological symptoms that worsen over time.

This test analyses multiple genes associated with iron metabolism and neurodegeneration using Next Generation Sequencing technology. It requires an EDTA blood sample and helps confirm a genetic diagnosis when clinical symptoms and imaging findings suggest NBIA.

What Does the Neurodegeneration with Brain Iron Accumulation Gene Panel Measure?

This genetic test looks for disease causing variants in genes linked to abnormal brain iron storage and neurodegeneration:

  • Detection of inherited NBIA related gene mutations
  • Confirmation of specific NBIA subtypes such as PKAN or PLAN
  • Differentiation of NBIA from other movement or neurodegenerative disorders
  • Support for prognosis assessment and long term care planning
  • Guidance for genetic counselling and family screening

Neurodegeneration with Brain Iron Accumulation Gene Panel: Who Needs It and Why It’s Done

What Symptoms May Call for a Neurodegeneration with Brain Iron Accumulation Gene Panel?

Doctors may suggest this test if you or your child experience:

  • Progressive muscle stiffness or dystonia
  • Difficulty walking or abnormal movements
  • Developmental regression in children
  • Parkinsonism like symptoms at a young age
  • Cognitive decline or behavioural changes
  • Brain MRI findings showing iron deposition

Who Should Get a Neurodegeneration with Brain Iron Accumulation Gene Panel?

This test may be recommended for:

  • Children or adults with suspected NBIA based on symptoms and imaging
  • Individuals with early onset movement disorders of unknown cause
  • Patients with progressive neurodegenerative symptoms
  • Families with a known history of NBIA
  • Couples with a genetic risk planning future pregnancies

Why is the Neurodegeneration with Brain Iron Accumulation Gene Panel Done?

  • The test helps confirm the genetic cause of NBIA, enabling accurate diagnosis, appropriate symptom management, informed family counselling, and avoidance of unnecessary investigations.

Importance of the Neurodegeneration with Brain Iron Accumulation Gene Panel

  • NBIA disorders are rare and often challenging to diagnose based on symptoms alone. Genetic confirmation helps clarify the exact subtype, predict disease progression, guide supportive treatment, and provide families with clear information about inheritance patterns and future risks.

Neurodegeneration with Brain Iron Accumulation Gene Panel Booking & Reports – Metropolis Healthcare

How to Book the Neurodegeneration with Brain Iron Accumulation Gene Panel and Get Your Reports?

  1. Simple Online Booking
    Booking can be done through the Metropolis Healthcare App or website. Select the Neurodegeneration with Brain Iron Accumulation Gene Panel, choose a convenient time slot, and provide your address for a blood test at home. You may also visit a nearby Metropolis Lab if you prefer in person sample collection.
  2. Safe Home Sample Collection
    Trained phlebotomists collect your blood sample while strictly following safety and hygiene protocols.
  3. Sample Tracking Updates
    You receive updates at every stage, from sample collection to testing, through the Metropolis Healthcare platform.
  4. Accurate Laboratory Testing
    Your sample is processed at NABL and CAP accredited laboratories using advanced molecular diagnostic technology.
  5. Quick and Easy Reports
    Your reports are shared via email, WhatsApp, or can be downloaded from the Metropolis Healthcare website or app.

Is Home Sample Collection for Neurodegeneration with Brain Iron Accumulation Gene Panel Available Near You?

Yes, Metropolis Healthcare offers home sample collection for the Neurodegeneration with Brain Iron Accumulation Gene Panel. This service reduces travel, ensures professional sample handling, and maintains strict quality standards throughout the testing process.

How Long Does It Take to Get a Neurodegeneration with Brain Iron Accumulation Gene Panel Report?

Reports are usually available after 4 weeks once the sample reaches the lab.
Note: Reporting time may vary based on your location.

Where Can I See or Get Neurodegeneration with Brain Iron Accumulation Gene Panel Results?

  1. You can view and download your test results through the Metropolis Healthcare website or mobile app.
    Reports are also sent via email or WhatsApp, and a physical copy can be collected from the Metropolis Lab if required.

Interpreting Neurodegeneration with Brain Iron Accumulation Gene Panel Results

What Your Neurodegeneration with Brain Iron Accumulation Gene Panel Results May Indicate

Parameter Expected Finding Pathogenic Variant Detected May Indicate No Variant Detected May Indicate
NBIA related genes No disease causing variant detected Genetic NBIA subtype affecting brain iron metabolism Symptoms may be due to other neurodegenerative conditions

Understanding Abnormal Neurodegeneration with Brain Iron Accumulation Gene Panel Results by Gene Group

Gene Group What a Pathogenic Variant May Indicate
PANK2, COASY Pantothenate kinase associated neurodegeneration
PLA2G6 PLA2G6 associated neurodegeneration
C19orf12 Mitochondrial membrane protein associated neurodegeneration
WDR45 Beta propeller protein associated neurodegeneration
CP, FTL Disorders of brain iron handling and storage

How Should You Prepare for a Neurodegeneration with Brain Iron Accumulation Gene Panel?

This genetic test needs minimal preparation:

  • No fasting required
  • Maintain normal hydration
  • Inform your doctor about current medications
  • Share detailed clinical and family history
  • Ensure test requisition and consent forms are completed

How Is a Neurodegeneration with Brain Iron Accumulation Gene Panel Done? (Step-by-Step Procedure)

The test is carried out using a standard blood collection process:

  • Preparation: A tourniquet is tied around your arm to make veins more visible
  • Cleaning: The puncture site is cleaned with antiseptic
  • Sample Collection: A sterile needle is used to draw about 3 to 5 ml of blood into an EDTA vacutainer
  • Completion: The needle is removed, and a bandage is applied
  • Processing: The sample is analysed using Next Generation Sequencing to identify disease causing genetic variants

Conditions That May Affect Neurodegeneration with Brain Iron Accumulation Gene Panel Accuracy

Certain patient related factors may influence interpretation:

  • Recent blood transfusion
  • Incomplete or unclear clinical history
  • Mosaic genetic variants that are difficult to detect
  • Variants of uncertain significance requiring further evaluation

Diseases That a Neurodegeneration with Brain Iron Accumulation Gene Panel Can Help Detect

  • Pantothenate kinase associated neurodegeneration
  • PLA2G6 associated neurodegeneration
  • Mitochondrial membrane protein associated neurodegeneration
  • Beta propeller protein associated neurodegeneration
  • Other inherited NBIA disorders

References

  1. Gregory A., Hayflick S.J. (2013). Neurodegeneration with brain iron accumulation disorders overview. GeneReviews, University of Washington. PMID: 20301658
  2. Kruer M.C., Boddaert N., Schneider S.A., et al. (2012). Neuroimaging features of neurodegeneration with brain iron accumulation. AJNR American Journal of Neuroradiology, 33(3), 407–414. PMID: 22116112
  3. Hayflick S.J., Westaway S.K., Levinson B., et al. (2003). Genetic, clinical, and radiographic delineation of Hallervorden Spatz syndrome. New England Journal of Medicine, 348(1), 33–40. PMID: 12510038
  4. Schneider S.A., Hardy J., Bhatia K.P. (2009). Syndromes of neurodegeneration with brain iron accumulation. Movement Disorders, 24(8), 1143–1151. PMID: 19412928

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

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  • Real-time tracking of phlebotomist arrival and report generation
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  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

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Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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