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NextGen Homologous Recombinant Deficiency Panel by NGS, FFPE Tissue**
₹ 110000
NextGen Homologous Recombination Deficiency Panel , Tissue
₹ 110000 ₹ 110000

NextGen Homologous Recombination Deficiency Panel , Tissue

Sample Type 51+ booked in last 3 days
Precaution
Report
Within 4 Weeks

NextGen Homologous Recombinant Deficiency Panel by NGS, FFPE Tissue** Price

₹ 110000

Brief Details

Preparation
Clinical history is required; the histopathology report of the block and the medical prescription are mandatory.
Also Known As
NextGen Homologous Recombination Deficiency Panel Tissue
Fasting
Not required
Reporting Time
After 4 weeks
Purpose
Analyses HRR pathway mutations in tumour tissue samples, aids in identifying patients eligible for PARP inhibitor therapy, and supports genetically based treatment decisions in ovarian, breast, and prostate cancers.

What Is a NextGen Homologous Recombination Deficiency Panel Tissue? 

A NextGen Homologous Recombination Deficiency Panel Tissue is an advanced genetic test that analyses cancer tissue samples using Next-Generation Sequencing (NGS) technology. This test examines your tumour's DNA to identify specific weaknesses in how cancer cells repair damage to their genetic material. 

The test helps doctors determine whether your cancer has homologous recombination deficiency, which makes certain targeted treatments more effective for your specific condition. 

What Does the NextGen Homologous Recombination Deficiency Panel Tissue Measure? 

This comprehensive test evaluates your cancer tissue's genetic characteristics to guide personalised treatment decisions: 

  • DNA repair gene mutations: Identify harmful changes in genes like BRCA1, BRCA2, and other essential DNA repair genes.
    • HRD score calculation: Measures genomic instability patterns that indicate deficient homologous recombination repair mechanisms.
    • Genomic scarring patterns: Detects specific damage signatures left by faulty DNA repair systems over time. 
    • Treatment response prediction: Determines the likelihood of responding to PARP inhibitor medications. 
    • Hereditary mutation detection: Identifies both inherited and acquired genetic changes affecting DNA repair. 

NextGen Homologous Recombination Deficiency Panel Tissue: Who Needs It and Why It's Done 

What Symptoms May Call for a NextGen Homologous Recombination Deficiency Panel Tissue? 

This test doesn't diagnose symptoms directly, as HRD is a characteristic of cancer tissue rather than a condition causing specific symptoms. However, your doctor may recommend this test if you've been diagnosed with certain cancers that commonly show symptoms such as abdominal bloating, pelvic discomfort, changes in bowel habits, or feeling full quickly. 

Who Should Get a NextGen Homologous Recombination Deficiency Panel Tissue? 

This specialised test is recommended for specific cancer patients to guide their treatment decisions: 

  • Patients with advanced cancers: Those diagnosed with ovarian cancer with symptoms such as abdominal bloating, pelvic discomfort, changes in bowel habits, or feeling full quickly
    • Recurrent cancer cases: Individuals whose cancer has returned after initial treatment
    • Family history patients: Those with a strong family history of breast or ovarian cancer, suggesting inherited mutations. 
    • Treatment planning candidates: Patients being considered for targeted therapy with PARP inhibitors. 

Why Is a NextGen Homologous Recombination Deficiency Panel Tissue Done? 

This test is performed to enable precision medicine by identifying whether your cancer has a specific vulnerability that can be targeted with PARP inhibitor drugs. It helps your oncologist choose the most effective treatment approach based on your cancer's unique genetic characteristics. 

Importance of a NextGen Homologous Recombination Deficiency Panel Tissue 

The NextGen HRD Panel represents a crucial advancement in precision oncology, offering hope and clarity in your cancer care journey. By identifying specific genetic vulnerabilities in your tumour, this test helps your medical team select the most effective treatments tailored specifically for your condition. 

When your cancer shows homologous recombination deficiency, it means the primary DNA repair system is compromised. PARP inhibitor medications can then block the backup repair system, causing cancer cells to die while leaving healthy cells largely unaffected. This targeted approach often results in better treatment outcomes, improved quality of life, and reduced side effects compared to traditional chemotherapy. 

The test serves as a predictive biomarker, helping your medical team make informed decisions about your treatment journey with confidence and precision. 

NextGen Homologous Recombination Deficiency Panel Tissue Booking & Reports – Metropolis Healthcare India 

How to Book a NextGen Homologous Recombination Deficiency Panel Tissue? 

  1. Simple Online Booking 
    Booking can be done through the Metropolis Healthcare App or website. Select the 'NextGen Homologous Recombination Deficiency Panel Tissue', choose a convenient time slot, and visit the nearest Metropolis Lab. 
     
  2. Sample Tracking Updates 
    Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. 
     
  3. Accurate Laboratory Testing 
    Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 
     
  4. Quick & Easy Reports 
    Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is Home Sample Collection for the NextGen Homologous Recombination Deficiency Panel Tissue Available Near You? 

No, Metropolis Healthcare does not provide home sample collection for the NextGen Homologous Recombination Deficiency Panel Tissue test. This specialised test requires tumour tissue samples that are typically collected during medical procedures like biopsies or surgeries at healthcare facilities. Our team coordinates with your healthcare provider to ensure your tissue sample reaches our NABL & CAP accredited pathology lab safely.  

How Long Does It Take to Get a NextGen Homologous Recombination Deficiency Panel Tissue Report? 

Reports are usually available within 4 weeks once the sample reaches the lab. 

Note: Reporting time may vary depending on your location. 

Where Can I See or Get NextGen Homologous Recombination Deficiency Panel Tissue Results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting NextGen Homologous Recombination Deficiency Panel Tissue Results 

What Your NextGen Homologous Recombination Deficiency Panel Tissue Results May Indicate 

Your test results provide crucial information about your tumour's genetic characteristics and treatment options: 

Parameters 

Result Interpretation 

Clinical Significance 

HRD Score 

≥50.0 indicates HRD-positive status. 
<50.0 indicates HRD-negative status. 

High scores suggest eligibility for PARP inhibitor therapy. 

Somatic HRR Study 

Clinically significant variants detected or not detected 

Acquired genetic changes in tumour cells, affecting treatment response 

Conditions that May Affect NextGen Homologous Recombination Deficiency Panel Tissue Accuracy 

Several factors related to tissue sample quality and processing can influence your test results: 

  • Tissue sample quality: Poorly preserved or inadequate tissue samples may affect genetic analysis accuracy.
    • Tumour content percentage: Low cancer cell content in the tissue sample may impact mutation detection.
    • Sample age and storage: Older samples or those stored improperly may show DNA degradation. 
    • Previous treatments: Chemotherapy or radiation therapy may alter tissue DNA quality. 
    • Fixation methods: Improper tissue fixation during biopsy processing can affect genetic material integrity. 
    • Sample contamination: Normal tissue mixed with cancer tissue may dilute genetic findings. 

How Is a NextGen Homologous Recombination Deficiency Panel Tissue Done? 

The HRD test involves several carefully coordinated steps to ensure accurate genetic analysis: 

  • Tissue sample collection: Your doctor obtains tumour tissue during a biopsy or surgical procedure.
    • Sample preparation: The tissue is processed and embedded in paraffin blocks for preservation.
    • DNA isolation: Genetic material is carefully extracted from cancer cells within the tissue sample. 
    • Library preparation: DNA is prepared for sequencing using specialised protocols for Next-Generation Sequencing. 
    • NGS sequencing: Advanced NGS sequencing technology reads millions of DNA sequences simultaneously. 
    • Bioinformatics analysis: Sophisticated computer algorithms analyse sequence data to identify mutations and calculate HRD score. 
    • Clinical interpretation: Expert pathologists review findings and provide treatment-relevant recommendations. 

How Should You Prepare for a NextGen Homologous Recombination Deficiency Panel Tissue? 

Preparing for your HRD test involves coordination with your medical team: 

  • No dietary restrictions: Your food intake does not affect tissue-based genetic testing.
    • Continue regular medications: Most medications don't interfere with the genetic analysis of tissue samples.
    • Provide a complete medical history: Share details about previous treatments, family history, and current health conditions. 
    • Bring histopathology reports: Ensure your doctor has access to previous tissue analysis results. 
    • Arrange medical prescription: This specialised test requires a prescription from your oncologist. 
    • Discuss timing: Coordinate with your treatment schedule, as results may influence therapy decisions. 

Diseases that a NextGen Homologous Recombination Deficiency Panel Tissue Can Help Detect 

This advanced genetic test provides valuable information for managing ovarian cancer, helping determine eligibility for PARP inhibitor maintenance therapy in patients with platinum-sensitive disease. 

NextGen Homologous Recombination Deficiency Panel Tissues/Packages that You Can Book With Metropolis Healthcare 

Metropolis Healthcare offers comprehensive cancer screening packages that complement your HRD testing: 

Test/Package Name 

Purpose/Highlights 

Cancer Marker Profile-Ovarian-Comprehensive 

Complete ovarian cancer screening with multiple tumour markers for early detection and monitoring 

Breast Carcinoma Profile I 

Comprehensive breast cancer assessment, including hormone receptors and HER2 status 

Prostate Profile Test 

Complete prostate health evaluation, including PSA and related markers for cancer screening 

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Choose precision On time, every time!

Precision
  • 98% on time collections with a 60 minutes promise
  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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About Us

Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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