EGFR Mutation Detection Test (EXONS 18, 19, 20, 21)
EGFR Mutation Detection (Exons -18, 19, 20, 21), FFPE Tissue Price
EGFR Mutation Test Overview
The EGFR mutation test is a crucial diagnostic tool that identifies specific genetic alterations in the Epidermal Growth Factor Receptor (EGFR) gene, particularly in exons 18, 19, 20, and 21. This test is primarily used to detect these mutations in patients with Non-Small Cell Lung Cancer (NSCLC), especially those with adenocarcinoma. By identifying the presence of EGFR mutations, the test helps determine whether a patient's tumour is likely to respond to targeted therapies such as Tyrosine Kinase Inhibitors (TKIs).
The EGFR mutation analysis provides valuable insights into the molecular characteristics of the tumour, enabling healthcare professionals to develop personalised treatment plans. By identifying patients who are likely to benefit from TKIs, the test helps optimise treatment outcomes and improve overall patient care. Additionally, the test can provide information about the aggressiveness of the disease and predict the patient's response to specific targeted therapies.
EFGR mutations are most commonly seen in Non-Small Cell Lung Cancer (NSCLC) adenocarcinomas. EFGR mutations tend to occur in women with little or no smoking history. The doctor may recommend testing if they suspect one has lung cancer. A biopsy is recommended if a person is already diagnosed with lung cancer, or if there is a recurrence of tumours in the patient.
Up to 20% of NSCLC tumors harbour the EGFR mutation in Exons 18-21, and that ~85% of patients with these patients respond to TKI treatment.
It’s pertinent that anyone with a diagnosis of lung cancer or those who are suspected of the disease should ask their doctor whether to get tested for EFGR. The doctor can use the same biopsy tissue used to diagnose lung cancer for testing for mutations.
Exons and introns are nucleic acid sequences made up of the polynucleotide chain. However, the structure of introns is more complex with high GC-rich regions and repetitive sequences. Both the exons and introns take part in protein formation and follow the DNA packaging mechanism to fit inside a cell.
Written by: Dr Vishal Wadhwa, M.D, D.N.B Microbiology, Medical Affairs
Frequently asked questions
Find quick answers to the most common questions about health tests, bookings, and reports.
Regular exercise, a balanced diet, avoiding smoking, maintaining a healthy weight, and managing stress all help reduce heart disease risk.
Common signs include irritability, trouble sleeping, headaches, difficulty concentrating, and muscle tension.
Ratings & Reviews
We're satisfying our customers every day since 1980.
Choose precision On time, every time!
- 98% on time collections with a 60 minutes promise
- Real-time tracking of phlebotomist arrival and report generation
- Fully digital report delivery—view from mobile or desktop instantly
- Continuous monitoring of turnaround times to ensure accuracy and speed
- Dedicated support team to resolve any delays or queries quickly
Why Metropolis Healthcare?
Metropolis has been present for over 40 years in the market.
Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
0
Years of experience
170+
Advanced Labs
Trusted by
Leading Doctors & Hospitals
2,000+
Scientific Officers
Proficiency Testing
for Accurate Reports
Latest Blogs & News
Stay informed with our expert insights and updates.
About Us
Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.
In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.