NextGen Colocore Targeted Panel -MMR ( IHC)
NextGen Colocore Targeted Panel -MMR ( IHC)** Price
Brief Details
What Is a Colocore Targeted Panel - MMR (IHC)?
The NextGen Colocore Targeted Panel - MMR (IHC) is a comprehensive genetic test that combines Next-Generation Sequencing (NGS) with Immunohistochemistry (IHC) techniques. This advanced test analyses tissue samples to identify specific genetic mutations and protein expressions in cancer cells, particularly focusing on colorectal and other related cancers.
This test helps detect mismatch repair deficiency (dMMR) and identifies key genetic mutations that can guide personalised cancer treatment decisions and assess your risk for hereditary cancer syndromes.
What Does the Colocore Targeted Panel - MMR (IHC) Measure?
This comprehensive test measures multiple important aspects of your cancer cells to guide treatment decisions:
- Mismatch Repair Proteins: Checks for the presence of four crucial DNA repair proteins (MLH1, MSH2, MSH6, and PMS2) that act as your body's natural "spell-checkers" for DNA.
- Key Cancer Gene Mutations: Analyse mutations in essential genes like TP53, KRAS, NRAS, and BRAF that drive cancer growth.
- Treatment Target Proteins: Identifies ERBB2 and NTRK proteins that can be targeted with specific therapies.
- Pathway Alterations: Examines PIK3CA mutations that affect cellular growth and survival pathways.
- Microsatellite Instability: Detects DNA repair system problems that may make tumours more responsive to certain treatments.
Colocore Targeted Panel - MMR (IHC): Who Needs It and Why It's Done
What Symptoms May Call for a Colocore Targeted Panel - MMR (IHC)?
The NextGen Colocore Targeted Panel - MMR (IHC) is typically ordered after a cancer diagnosis. The symptoms that might initially lead to cancer investigation include:
- Persistent changes in bowel habits, including diarrhoea or constipation
- Blood in stool or rectal bleeding
- Ongoing abdominal discomfort, cramps, or pain
- Feeling that your bowel doesn't empty completely
- Unexplained weight loss and persistent fatigue
- Abdominal bloating or feeling full quickly
Who Should Get a Colocore Targeted Panel - MMR (IHC)?
Healthcare providers recommend the NextGen Colocore Targeted Panel - MMR (IHC) for specific patient groups who can benefit from personalised cancer treatment:
- Patients with newly diagnosed colorectal cancer, regardless of age or family history.
- Individuals with endometrial, ovarian, gastric, or pancreatic cancers that may be associated with hereditary syndromes.
- Patients who require treatment guidance to determine the most effective therapy options.
- People with a strong family history of colorectal or related cancers, suggesting hereditary cancer syndromes and health risks.
- Patients who are being considered for immunotherapy to assess treatment suitability.
Why Is a Colocore Targeted Panel - MMR (IHC) Done?
The NextGen Colocore Targeted Panel – MMR (IHC) is performed to guide personalised cancer treatment by identifying specific genetic characteristics of your tumour and to screen for hereditary cancer syndromes that may affect you and your family members.
Importance of a Colocore Targeted Panel - MMR (IHC)
The NextGen Colocore Targeted Panel - MMR (IHC) plays a crucial role in modern precision cancer care. It is clinically vital for treatment selection, as tumours with mismatch repair deficiency often respond exceptionally well to immunotherapy treatments.
Additionally, abnormal MMR results can indicate Lynch syndrome, a hereditary condition that significantly increases cancer risk. This information enables enhanced screening for other potential cancers and allows family members to be tested, as they have a higher chance of inheriting the same genetic risk.
Colocore Targeted Panel - MMR (IHC) Booking & Reports – Metropolis Healthcare India
How to Book a Colocore Targeted Panel - MMR (IHC)?
- Simple Online Booking
Booking can be done through the Metropolis Healthcare App or website. Select the 'NextGen Colocore Targeted Panel - MMR (IHC)', choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab.
- Safe Home Sample Collection
Our trained phlebotomists ensure the timely collection of your sample while strictly following all safety and hygiene protocols.
- Sample Tracking Updates
Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website.
- Accurate Laboratory Testing
Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results.
- Quick & Easy Reports
Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app.
Is Home Sample Collection for the Colocore Targeted Panel - MMR (IHC) Available Near You?
Yes, home blood sample collection is available for the NextGen Colocore Targeted Panel - MMR (IHC) through Metropolis Healthcare. Our trained phlebotomists follow strict safety protocols while collecting your blood sample in the comfort of your home. However, your existing tumour tissue (FFPE block) from biopsy or surgery must be provided at the pathology lab. Our commitment to accessible testing means you can access this important cancer screening test wherever you are, making your healthcare journey smoother and more convenient.
How Long Does It Take to Get a Colocore Targeted Panel - MMR (IHC) Report?
Reports are usually available within 4 weeks once the sample reaches the pathology lab.
Note: Reporting time may vary depending on your location.
Where Can I See or Get Colocore Targeted Panel - MMR (IHC) Results?
Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab.
Interpreting Colocore Targeted Panel - MMR (IHC) Results
What Your Colocore Targeted Panel - MMR (IHC) Results May Indicate
Your test results will show the status of each parameter analysed, helping your doctor understand your cancer's genetic characteristics:
|
Parameter |
Normal Result |
Abnormal Result Significance |
|
MMR-IHC (MLH1, MSH2, MSH6, PMS2) |
Intact protein expression |
Loss of expression indicates a mismatch repair deficiency, suggesting Lynch syndrome risk and immunotherapy suitability. |
|
TP53 |
No mutation detected |
Mutations indicate altered tumour suppressor function affecting treatment response. |
|
KRAS/NRAS |
No mutation detected |
Mutations may affect the response to certain targeted therapies. |
|
BRAF |
No mutation detected |
Mutations can guide specific targeted therapy selection. |
|
ERBB2 |
No amplification |
Amplification indicates potential for HER2-targeted therapy. |
|
NTRK (1, 2, 3) |
No fusion detected |
Fusions indicate eligibility for NTRK inhibitor therapy. |
|
PIK3CA |
No mutation detected |
Mutations may influence treatment selection and prognosis. |
Conditions that May Affect Colocore Targeted Panel - MMR (IHC) Accuracy
Several factors can influence the accuracy of NextGen Colocore Targeted Panel - MMR (IHC) results and should be discussed with your healthcare team:
- Tissue sample quality: Poor preservation or insufficient tissue can affect test reliability.
- Previous chemotherapy or radiation: These treatments may alter tissue characteristics and test results.
- Sample age and storage conditions: Older samples or improper storage may degrade genetic material.
- Tumour heterogeneity: Different areas of the same tumour may show varying genetic characteristics.
- Concurrent medications: Certain drugs may interfere with tissue preservation or analysis.
How Is a Colocore Targeted Panel - MMR (IHC) Done?
The NextGen Colocore Targeted Panel - MMR (IHC) involves both blood sample collection and tissue analysis in a systematic process:
- Blood sample collection: A trained phlebotomist collects 3 ml of blood in an EDTA tube using sterile techniques.
- Tissue block preparation: Your existing tumour tissue (FFPE block) from biopsy or surgery is used for analysis.
- Sample transportation: Both samples are transported to the laboratory under appropriate temperature conditions.
- DNA extraction: Genetic material is carefully extracted from both blood and tissue samples.
- Next Generation Sequencing: Advanced NGS technology analyses multiple genes simultaneously for mutations.
- Immunohistochemistry staining: Special staining techniques identify the presence or absence of MMR proteins.
- Data analysis: Sophisticated software analyses the genetic and protein data.
- Report generation: Results are compiled into a comprehensive report for your doctor.
How Should You Prepare for a Colocore Targeted Panel - MMR (IHC)?
Preparing for this test is straightforward and requires minimal preparation on your part:
- No fasting required: You can eat and drink normally before the blood collection.
- Continue regular medications: Unless specifically advised otherwise by your doctor.
- Bring clinical history: Ensure your histopathology and IHC reports are available.
- Comfortable clothing: Wear clothes that allow easy access to your arm for blood collection.
- Stay hydrated: Drink adequate water to make blood collection easier.
Diseases that a Colocore Targeted Panel - MMR (IHC) Can Help Detect
This comprehensive test can help identify and characterise specific cancer types and hereditary health conditions:
- Colorectal cancer
- Lynch syndrome
Colocore Targeted Panel - MMR (IHC)/Packages that You Can Book With Metropolis Healthcare
Metropolis Healthcare offers comprehensive cancer testing options to support your diagnostic and treatment journey:
|
Test/Package Name |
Purpose/Highlights |
|
Colectomy Histopathology, KRAS mutations, Special stains & Reflex IHC Test |
Detailed tissue analysis after colon surgery for comprehensive cancer staging |
|
Specific testing for KRAS gene mutations to guide targeted therapy decisions |
|
|
Targeted testing for BRAF mutations is important for treatment selection. |
|
|
Comprehensive genetic profiling to identify treatment opportunities |
|
Test/Package Name |
Purpose/Highlights |
|
Colectomy Histopathology, KRAS mutations, Special stains & Reflex IHC Test |
Detailed tissue examination after colon surgery |
|
Extensive genetic profiling for personalised cancer treatment |
|
|
Measures total genetic changes to predict immunotherapy response |
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Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.
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