TPMT and NUDT15 Gene Analysis
TPMT and NUDT15 Gene Detection, EDTA Blood Price
TPMT and NUDT15 gene analysis is a genetic test performed before treatment with thiopurine medications. Thiopurines are powerful drugs used to treat various conditions like leukemia and inflammatory bowel disease (IBD). However, these medications can have a severe side effect called neutropenia, a dangerous decrease in white blood cells that fight infection. The TPMT and NUDT15 genes provide instructions for enzymes that help break down thiopurines. Variations in these genes can affect how efficiently the body processes the drugs. This test analyzes these genes to identify individuals at increased risk of neutropenia from standard thiopurine doses. By knowing a patient's TPMT and NUDT15 status, doctors can adjust the medication dosage to optimize treatment effectiveness while minimizing the risk of this serious side effect.
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