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NextGen Liquicore Paradigm Panel by NGS, Peripheral Blood**
₹ 180000
Next Gen LiquiCore Paradigm
₹ 180000 ₹ 180000

Next Gen LiquiCore Paradigm

Sample Type 51+ booked in last 3 days

NextGen Liquicore Paradigm Panel by NGS, Peripheral Blood** Price

₹ 180000

What Is a NextGen LiquiCore Paradigm Test? 

The NextGen LiquiCore Paradigm Test is an advanced next-generation sequencing (NGS) assay that analyses circulating tumour DNA (ctDNA) from your blood sample. This sophisticated test examines 501 clinically relevant genes to identify genetic changes that drive cancer growth and spread. 

The test helps detect genetic mutations in cancer cells, determines tumour mutation burden, and identifies microsatellite instability to guide personalised cancer treatment decisions. 

What Does the NextGen LiquiCore Paradigm Test Measure? 

This advanced test provides comprehensive information about your cancer's genetic profile: 

  • Genetic mutations: Identifies specific DNA changes in cancer cells that can guide targeted therapy selection.
    • Tumour mutation burden (TMB): Measures the total number of mutations in your tumour to predict response to immunotherapy.
    • Microsatellite instability (MSI): Detects genetic instability that may indicate a better response to certain treatments. 
    • Gene fusions and alterations: Identifies when parts of genes have joined together abnormally, which can drive cancer growth. 
    • Circulating tumour DNA (ctDNA): Analyses cancer DNA fragments present in your bloodstream. 
  • Treatment guidance: Matches detected mutations with FDA-approved targeted therapies.
    • Drug resistance monitoring: Identifies genetic changes that may cause treatment resistance.

NextGen LiquiCore Paradigm Test: Who Needs It and Why It's Done 

What Symptoms May Call for a NextGen LiquiCore Paradigm Test? 

Your doctor may recommend this NGS sequencing test if you experience symptoms related to various cancers: 

  • Persistent, unexplained weight loss despite normal eating habits
  • Chronic cough or breathing difficulties that don't improve with treatment
  • New lumps or masses detected anywhere in your body
  • Changes in bowel habits or blood in stool
  • Extreme fatigue that doesn't improve with rest
  • Recurring infections or slow-healing wounds
  • Unusual bleeding or bruising patterns

Who Should Get a NextGen LiquiCore Paradigm Test? 

This advanced test is recommended for specific patient groups who can benefit from personalised cancer care: 

  • Those with a confirmed cancer diagnosis: Particularly those with health conditions such as lung, breast, colorectal, or other solid tumours.
    • Patients requiring treatment selection: When doctors need to choose the most effective targeted therapy.
    • Patients with treatment-resistant cancer: When current treatments are not working effectively. 
    • Individuals unsuitable for tissue biopsy: When obtaining tumour tissue samples is difficult or risky. 
    • People needing treatment monitoring: To track how well current therapies are working. 

Why Is a NextGen LiquiCore Paradigm Test Done? 

This test enables personalised cancer treatment by matching specific genetic mutations in your tumour to the most effective targeted therapies available. It helps doctors make informed treatment decisions based on your cancer's unique genetic profile. 

Importance of a NextGen LiquiCore Paradigm Test 

The NextGen LiquiCore Paradigm Test represents a significant advancement in precision oncology care. This comprehensive genetic analysis moves beyond traditional one-size-fits-all chemotherapy approaches by identifying specific mutations driving your cancer's growth. 

The test provides complete genetic profiling that captures DNA from various tumour sites, offering a more dynamic view of cancer evolution. Its non-invasive nature allows for ongoing monitoring through simple blood draws, making it safer and more convenient than repeated tissue biopsies. This enables early detection of treatment resistance and disease progression, allowing timely treatment adjustments for optimal patient outcomes. 

NextGen LiquiCore Paradigm Test Booking & Reports – Metropolis Healthcare India 

How to Book a NextGen LiquiCore Paradigm Test? 

  1. Simple Online Booking 
    Booking can be done through the Metropolis Healthcare App or website. Select the 'NextGen LiquiCore Paradigm Test', choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab. 
     
  2. Safe Home Sample Collection 
    Our trained phlebotomists ensure the timely collection of your sample while strictly following all safety and hygiene protocols. 
     
  3. Sample Tracking Updates 
    Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. 
     
  4. Accurate Laboratory Testing 
    Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 
     
  5. Quick & Easy Reports 
    Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is Home Sample Collection for the NextGen LiquiCore Paradigm Test Available Near You? 

Yes, Metropolis Healthcare provides home blood sample collection for the NextGen LiquiCore Paradigm Test across India. Our trained phlebotomists visit your doorstep with specialised collection tubes and follow strict safety protocols. This convenient service ensures you receive the same accurate, reliable results from our NABL & CAP accredited laboratories without the stress of travelling to a pathology lab during your cancer care journey. 

How Long Does It Take to Get a NextGen LiquiCore Paradigm Test Report? 

Reports are usually available within 25 days once the sample reaches the lab. 

Note: Reporting time may vary depending on your location. 

Where Can I See or Get NextGen LiquiCore Paradigm Test Results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting NextGen LiquiCore Paradigm Test Results 

What Your NextGen LiquiCore Paradigm Test Results May Indicate 

The following table explains the key components of your test results and their clinical significance: 

Parameter 

Result Categories 

Clinical Significance 

Genomic Alterations 

Detected/Not Detected 

Detected mutations may have FDA-approved targeted therapies available. 

Tumour Mutation Burden 

Low (1-5 mutations/Mb) 
Intermediate (6-19 mutations/Mb) 
High (>20 mutations/Mb) 

Higher TMB may indicate a better response to immunotherapy. 

Microsatellite Instability 

Stable/Unstable 

MSI-High tumours typically respond well to immunotherapy. 

Conditions that May Affect NextGen LiquiCore Paradigm Test Accuracy 

Several factors can influence your test results and should be discussed with your doctor: 

  • Recent chemotherapy or radiation therapy: May temporarily reduce circulating tumour DNA levels.
    • Sample timing: Ideally collected 3 weeks after therapy for optimal results.
    • Blood clotting or haemolysis: Can interfere with DNA analysis quality 
    • Insufficient sample volume: May lead to inconclusive results 
    • Certain medications: Some treatments may affect tumour DNA shedding patterns. 
    • Sample storage and transport conditions: Improper handling can degrade genetic material. 

How Is a NextGen LiquiCore Paradigm Test Done? 

The test follows a systematic process to ensure accurate genetic analysis: 

  • Blood sample collection: Two specialised Streck tubes are filled with 9-9.5 ml of blood each.
    • Sample preservation: Special tubes maintain DNA integrity during transport to the laboratory.
    • DNA extraction: Circulating tumour DNA is carefully isolated from your blood sample. 
    • Next-generation sequencing: Advanced technology analyses 531 genes for mutations and alterations. 
    • Bioinformatics analysis: Sophisticated software interprets genetic data and identifies clinically relevant findings. 
    • Report generation: Results are compiled into a comprehensive report with treatment recommendations. 

How Should You Prepare for a NextGen LiquiCore Paradigm Test? 

Preparing for this test is straightforward with minimal requirements: 

  • No fasting required: You can eat and drink normally before the test.
    • Continue regular medications: Take all prescribed medicines as usual unless specifically instructed otherwise by your doctor.
    • Provide clinical history: Share detailed information about your cancer diagnosis, treatments received, and current medications. 
    • Schedule appropriately: Ideally, the test should be done 3 weeks after your last therapy session for optimal results. 
  • Wear comfortable clothing: Choose clothing with sleeves that can be easily rolled up for blood collection.

Diseases that a NextGen LiquiCore Paradigm Test Can Help Detect 

This comprehensive genetic test can provide valuable information for various cancer types: 

  • Lung cancer: Identifies mutations like EGFR, ALK, ROS1, and KRAS that guide targeted therapy selection
  • Breast cancer: Detects HER2 amplifications, PIK3CA mutations, and other actionable genetic changes
  • Colorectal cancer: Identifies KRAS, NRAS, and BRAF mutations and microsatellite instability status
  • Prostate cancer: Detects DNA repair gene mutations and other therapeutic targets
  • Ovarian cancer: Identifies BRCA1/2 mutations and homologous recombination deficiency
  • Melanoma: Detects BRAF, NRAS, and other mutations relevant for targeted therapy
  • Gastrointestinal cancers: Identifies various genetic alterations across stomach, pancreatic, and liver cancers

NextGen LiquiCore Paradigm Test/Packages that You Can Book With Metropolis Healthcare 

Metropolis Healthcare offers comprehensive cancer genetic testing options to support your personalised treatment journey: 

Test/Package Name 

Purpose/Highlights 

NGS Lung Panel Test 

Targeted genetic analysis for lung cancer-specific mutations 

Tumour Mutation Burden NGS 

Comprehensive TMB assessment for immunotherapy eligibility 

Microsatellite Instability (MSI)/HNPCC/Lynch Syndrome, PCR 

Specific MSI detection for hereditary cancer syndromes 

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

Regular exercise, a balanced diet, avoiding smoking, maintaining a healthy weight, and managing stress all help reduce heart disease risk.

Common signs include irritability, trouble sleeping, headaches, difficulty concentrating, and muscle tension.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Choose precision On time, every time!

Precision
  • 98% on time collections with a 60 minutes promise
  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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About Us

Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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