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NextGen GeneCORE Paradigm Panel by NGS, FFPE Tissue**
₹ 140000
NextGen geneCORE Paradigm
₹ 140000 ₹ 140000

NextGen geneCORE Paradigm

Sample Type 51+ booked in last 3 days
Precaution
Report
Within 4 Weeks

NextGen GeneCORE Paradigm Panel by NGS, FFPE Tissue** Price

₹ 140000

Brief Details

Preparation
Clinical history is required; the histopathology report of the block and the medical prescription are mandatory.
Also Known As
NextGen GeneCORE Paradigm
Fasting
Not required
Reporting Time
After 20 days
Purpose
A comprehensive genomic analysis for personalised oncology treatment, aids in detecting actionable mutations in various cancers, and supports precision medicine approaches for targeted therapy.

What Is a NextGen GeneCORE Paradigm? 

The NextGen GeneCORE Paradigm is an advanced Next Generation Sequencing (NGS) test that analyses your DNA to identify genetic changes or mutations in 553 clinically relevant genes. This comprehensive genomic test examines both DNA and RNA from tissue samples to detect specific alterations that may influence cancer development, progression, and treatment response. 

The test helps detect actionable mutations across various cancers, supports precision medicine approaches to targeted therapy, and assists in identifying suitable candidates for immunotherapy. 

What Does the NextGen GeneCORE Paradigm Measure? 

This NGS sequencing test serves several important purposes in cancer care: 

  • Identifies actionable mutations: Detects specific genetic changes in your tumour that can be targeted with approved medications.
    • Assesses tumour mutation burden (TMB): Measures the total number of mutations in your cancer cells to predict immunotherapy response.
    • Evaluates microsatellite instability (MSI): Determines if your tumour has defects in DNA repair mechanisms. 
    • Analyses homologous recombination repair (HRR) pathway: Identifies deficiencies that may respond to specific targeted treatments. 
    • Supports clinical trial enrolment: Provides genetic information needed for participation in relevant research studies. 
    • Guides precision medicine approaches: Enables doctors to select the most appropriate targeted therapies based on your tumour's unique genetic profile. 

NextGen GeneCORE Paradigm: Who Needs It and Why It's Done 

What Symptoms May Call for a NextGen GeneCORE Paradigm? 

Your doctor may recommend this test based on specific medical situations rather than common symptoms: 

  • Confirmed cancer diagnosis, particularly advanced, rare, or treatment-resistant cases.
    • A strong family history of cancer, especially multiple relatives diagnosed at young ages.
    • Complex or rare diseases that remain undiagnosed after other tests. 
    • Cancer that has not responded well to standard treatments. 
    • Need for personalised treatment planning in oncology care. 
    • Eligibility assessment for targeted therapy or immunotherapy. 

Who Should Get a NextGen GeneCORE Paradigm? 

This advanced genetic test is recommended for specific patient groups: 

  • Cancer patients: Individuals with confirmed cancer diagnoses requiring personalised treatment approaches.
    • High-risk individuals: People with significant health risks, like family histories of cancer or genetic disorders.
    • Treatment-resistant cases: Patients whose cancers have not responded to conventional therapies. 
    • Precision medicine patients: Those seeking targeted therapy options based on their tumour's genetic profile. 

Why Is a NextGen GeneCORE Paradigm Done? 

This test enables doctors to move from standard treatment approaches to personalised medicine, allowing for highly specific diagnostic, therapeutic, and prognostic decisions based on your unique genetic makeup and tumour characteristics. 

Importance of a NextGen GeneCORE Paradigm 

The NextGen GeneCORE Paradigm represents a cornerstone of modern precision oncology, offering transformative clinical benefits for cancer patients. By identifying the exact genetic alterations driving your cancer's growth, this test enables doctors to select targeted therapies that attack cancer cells directly while sparing healthy tissue. 

This comprehensive analysis helps determine your likelihood of responding to immunotherapy, guides clinical trial enrolment, and provides crucial information for treatment planning. The test's ability to assess tumour mutation burden and microsatellite instability status has led to significantly improved outcomes in various cancer types, making it an essential tool in contemporary cancer care. 

NextGen GeneCORE Paradigm Booking & Reports – Metropolis Healthcare India 

How to Book a NextGen GeneCORE Paradigm? 

  1. Simple Online Booking 
    Booking can be done through the Metropolis Healthcare App or website. Select the 'NextGen GeneCORE Paradigm', choose a convenient time slot, and visit the nearest Metropolis Lab. 
     
  2. Sample Tracking Updates 
    Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. 
     
  3. Accurate Laboratory Testing 
    Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 
     
  4. Quick & Easy Reports 
    Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is Home Sample Collection for the NextGen GeneCORE Paradigm Available Near You? 

No, Metropolis Healthcare does not provide home sample collection for the NextGen GeneCORE Paradigm test. This specialised test requires a tissue sample (FFPE block) that's typically obtained through biopsy procedures performed in hospital settings. Your tissue samples are handled by trained professionals following strict protocols at our NABL & CAP accredited pathology lab. 

How Long Does It Take to Get a NextGen GeneCORE Paradigm Report? 

Reports are usually available within 20 days once the sample reaches the lab. 

Note: Reporting time may vary depending on your location. 

Where Can I See or Get NextGen GeneCORE Paradigm Results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting NextGen GeneCORE Paradigm Results 

What Your NextGen GeneCORE Paradigm Results May Indicate 

Your comprehensive genetic report provides detailed information about various biomarkers and their clinical significance: 

Parameters 

Reference Range/Categories 

Clinical Significance 

Tumour Mutation Burden (TMB) 

Low: 1-5 mutations/Mb 
Intermediate: 6-19 mutations/Mb 
High: >20 mutations/Mb 

Low: Unlikely to benefit from immunotherapy 
Intermediate: Moderate immunotherapy response 
High: Good immunotherapy response expected 

Microsatellite Instability (MSI) 

Stable/Unstable 

Stable: Normal DNA repair 
Unstable: May respond well to immunotherapy 

Genetic Variants 

Tier 1-4 Classification 

Tier 1: Variants with strong clinical significance for therapy, prognosis and diagnosis for the same tumour type  

Tier 2: Variants with potential clinical significance for therapy, prognosis and diagnosis for the different tumour types  

Tier 3: Variants of unknown clinical significance (VUS)  

Tier 4: Variants deemed benign or likely benign. 

HRR Pathway Genes Status 

Positive/Negative 

Positive: Deficiency detected, may benefit from PARP inhibitors 
Negative: No significant deficiency detected 

Conditions that May Affect NextGen GeneCORE Paradigm Accuracy 

Several factors can influence the quality and accuracy of your NextGen GeneCORE Paradigm results: 

  • Tissue quality and tumour content: Insufficient tumour cells or poor tissue preservation may affect analysis.
    • Sample fixation methods: Improper formalin fixation can degrade DNA and RNA quality.
    • Storage conditions: Inappropriate temperature or prolonged storage may compromise sample integrity. 
    • Contamination: Cross-contamination with normal tissue or other samples can alter results. 
    • Technical factors: Laboratory processing conditions and sequencing quality control standards. 
    • Tumour heterogeneity: Different areas of the same tumour may have varying genetic profiles. 
    • Previous treatments: Chemotherapy or radiation may alter the genetic landscape of tumours. 

How Is a NextGen GeneCORE Paradigm Done? 

The NextGen GeneCORE Paradigm follows a sophisticated multi-step process to analyse your tissue sample: 

  • Tissue preparation: Your formalin-fixed, paraffin-embedded tissue block is sectioned and prepared for analysis.
    • Quality assessment: Pathologists evaluate tumour content and tissue quality to ensure an adequate sample.
    • DNA and RNA extraction: Genetic material is carefully extracted from the tissue using specialised techniques. 
    • Library preparation: DNA and RNA are processed and prepared for sequencing analysis. 
    • Next-generation sequencing: Advanced sequencing technology analyses all 553 genes simultaneously. 
    • Bioinformatics analysis: Sophisticated computer algorithms identify mutations, variants, and biomarkers. 
    • Clinical interpretation: Expert pathologists review findings and provide therapeutic recommendations. 

How Should You Prepare for a NextGen GeneCORE Paradigm? 

Preparing for this test requires coordination with your healthcare team: 

  • Provide clinical history: Share detailed information about your health condition, cancer diagnosis and treatments with your doctor.
    • Submit histopathology report: Ensure your tissue biopsy report accompanies the sample for proper analysis.
    • Obtain a medical prescription: Your oncologist must provide a prescription for this specialised genetic test. 
    • Consultation scheduling: Plan follow-up appointments to discuss results with your oncologist. 
    • No dietary restrictions: Unlike blood tests, this tissue-based test doesn't require fasting or dietary preparation. 

Diseases that a NextGen GeneCORE Paradigm Can Help Detect 

This comprehensive genetic test provides valuable insights for various cancer types and conditions: 

  • Lung cancer: Including non-small cell lung cancer with targetable mutations
    • Breast cancer: Particularly hormone receptor-positive and triple-negative subtypes
    • Colorectal cancer: Including microsatellite unstable tumours responsive to immunotherapy 
    • Ovarian cancer: Especially tumours with homologous recombination deficiencies 
    • Pancreatic cancer: Including hereditary cancer syndromes and targetable mutations 
    • Brain tumours: Such as gliomas with IDH mutations and other actionable alterations 
    • Sarcomas: Rare tumours requiring specialised genetic characterisation for treatment selection. 

NextGen GeneCORE Paradigm/Packages that You Can Book With Metropolis Healthcare 

Metropolis Healthcare offers several related genetic and cancer screening tests to complement your diagnostic needs: 

Test/Package Name 

Purpose/Highlights 

Tumour Mutation Burden NGS 

Specific assessment of mutation load for immunotherapy guidance 

Tumour Marker Panel (270 Genes), Comprehensive, FFPE 

Focused genetic analysis for targeted cancer treatment 

Tumour/Cancer Marker Profile Test 

Comprehensive screening for multiple cancer biomarkers 

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Choose precision On time, every time!

Precision
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  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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About Us

Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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