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Lissencephaly gene panel
₹ 19400
Lissencephaly Gene Panel
₹ 19400 ₹ 19400

Lissencephaly Gene Panel

Sample Type 51+ booked in last 3 days
Precaution
Sample Type
Swab
Precaution
Fasting
Yes
Precaution
Report
Within 4 Weeks

Lissencephaly gene panel Price

₹ 19400

Brief Details

Preparation
No special preparation required
Also Known As
Lissencephaly Gene Panel by NGS
Fasting
Fasting not required
Reporting Time
After 4 weeks
Purpose
To detect genetic mutations causing lissencephaly and support diagnosis, management, and family risk assessment

What is the Lissencephaly Gene Panel?

The Lissencephaly Gene Panel is a genetic blood test used to identify inherited conditions that affect normal brain development. Lissencephaly is a brain malformation disorder where the surface of the brain appears smooth due to abnormal neuronal migration during early development.

This test analyses multiple genes associated with cortical development using Next Generation Sequencing technology. It requires an EDTA blood sample and helps doctors confirm a genetic diagnosis, understand disease type, and assess risks for other family members.

What Does the Lissencephaly Gene Panel Measure?

This genetic test evaluates changes in genes involved in brain formation and neuronal migration:

  • Detection of disease causing variants linked to lissencephaly
  • Differentiation of lissencephaly from other cortical migration disorders
  • Identification of inherited causes of severe developmental delay and seizures
  • Support for clinical diagnosis and long term neurological care planning
  • Guidance for genetic counselling, family screening, and prenatal evaluation

Lissencephaly Gene Panel: Who Needs It and Why It’s Done

What Symptoms May Call for a Lissencephaly Gene Panel?

Doctors may recommend this test if you or your child experience symptoms such as:

  • Severe developmental delay from infancy
  • Seizures that begin early in life
  • Poor muscle tone or abnormal stiffness
  • Feeding difficulties and failure to thrive
  • Abnormal brain imaging findings on MRI

Who Should Get a Lissencephaly Gene Panel?

  • Infants or children with suspected brain malformation disorders
  • Individuals with MRI findings suggestive of lissencephaly
  • Patients with unexplained seizures and developmental delay
  • Individuals with a family history of cortical development disorders
  • Couples planning a pregnancy with known genetic risk

Why is a Lissencephaly Gene Panel Done?

The test helps identify the genetic cause of lissencephaly, allowing accurate diagnosis, appropriate medical care, and informed family planning decisions.

Importance of the Lissencephaly Gene Panel

Early and precise diagnosis of lissencephaly is important for guiding medical care, seizure management, and developmental support. This gene panel enables identification of the underlying genetic condition, helping your doctor predict disease course, avoid unnecessary investigations, and provide appropriate counselling for long term care and family risk assessment.

Lissencephaly Gene Panel Booking & Reports – Metropolis Healthcare

How to Book the Lissencephaly Gene Panel and Get Your Reports?

  1. Simple Online Booking
    Booking can be done through the Metropolis Healthcare App or website. Select the Lissencephaly Gene Panel, choose a convenient time slot, and provide your address for a blood test at home. You may also visit a nearby Metropolis Lab if you prefer in person sample collection.
  2. Safe Home Sample Collection
    Trained phlebotomists collect your blood sample while strictly following safety and hygiene protocols.
  3. Sample Tracking Updates
    You receive updates at every stage, from sample collection to testing, through the Metropolis Healthcare platform.
  4. Accurate Laboratory Testing
    Your sample is processed at NABL and CAP accredited laboratories using advanced molecular diagnostic technology.
  5. Quick and Easy Reports
    Your reports are shared via email, WhatsApp, or can be downloaded from the Metropolis Healthcare website or app.

Is Home Sample Collection for Lissencephaly Gene Panel Available Near You?

Yes, Metropolis Healthcare offers home sample collection for the Lissencephaly Gene Panel. This service saves you time, reduces the need for travel, and ensures professional sample handling while maintaining strict quality standards.

How Long Does It Take to Get a Lissencephaly Gene Panel Report?

Reports are usually available after 4 weeks once the sample reaches the lab.
Note: Reporting time may vary based on your location.

Where Can I See or Get Lissencephaly Gene Panel Results?

  1. Metropolis Healthcare website or mobile app
    You can access your test results through the Metropolis Healthcare website or mobile app using your login credentials.
  2. Email or WhatsApp
    Reports are also shared via email or WhatsApp.
  3. Physical copy from the lab
    You may collect a physical copy directly from the Metropolis Lab if required.

Interpreting Lissencephaly Gene Panel Results

What Your Lissencephaly Gene Panel Results May Indicate

Parameter Expected Finding Pathogenic Variant Detected May Indicate No Variant Detected May Indicate
Lissencephaly related genes No disease causing variant detected Genetic lissencephaly or related cortical migration disorder Symptoms may be due to other neurological or genetic conditions

Understanding Abnormal Lissencephaly Gene Panel Test Results

Gene Group What a Pathogenic Variant May Indicate
DCX, PAFAH1B1, TUBA1A Classic lissencephaly with severe cortical malformation
RELN, VLDLR Reelin pathway disorders affecting neuronal migration
ARX, WDR62, DYNC1H1 Complex brain development disorders with seizures
POMT and POMGNT genes Muscular dystrophy associated lissencephaly spectrum

How Should You Prepare for a Lissencephaly Gene Panel?

This genetic test requires minimal preparation. Please keep the following points in mind:

  • No fasting required: You can eat and drink normally unless advised otherwise by your doctor
  • Normal hydration: Continue your usual fluid intake
  • Medication information: Inform your doctor about all medicines or supplements you are taking
  • Clinical history: Share relevant medical and family history to support accurate interpretation
  • Consent and forms: Ensure the test requisition form and genetic history details are completed

How Is a Lissencephaly Gene Panel Done? (Step-by-Step Procedure)

The test is performed using a simple blood collection process:

  • Preparation: A tourniquet is tied around your arm to make veins more visible.
  • Cleaning: The puncture site is cleaned with antiseptic.
  • Sample Collection: A sterile needle is used to draw about 3 to 5 ml of blood into an EDTA vacutainer.
  • Completion: The needle is removed, and a bandage is applied.
  • Processing: The sample is analysed using Next Generation Sequencing to identify gene mutations linked to lissencephaly.

Conditions That May Affect Lissencephaly Gene Panel Accuracy

Certain patient related factors may influence test interpretation:

  • Recent blood transfusion may affect genetic analysis
  • Incomplete or incorrect clinical history can limit interpretation
  • Mosaic genetic changes may be harder to detect in some individuals
  • Variants of uncertain significance may require further family testing

Diseases That a Lissencephaly Gene Panel Can Help Detect

  • Lissencephaly
  • Cortical migration disorders
  • Neuronal development disorders
  • Genetic brain malformation syndromes

References

  1. Guerrini R., Parrini E. (2010). Neuronal migration disorders. Neurobiology of Disease, 38(2), 154–166. PMID: 20096383
  2. Dobyns W.B., Mirzaa G.M. (2019). Megalencephaly and related cortical malformations. Nature Reviews Neurology, 15(10), 585–601. PMID: 31406348
  3. Poirier K., Saillour Y., Bahi Buisson N., et al. (2007). Mutations in the neuronal migration gene DCX cause lissencephaly. Human Molecular Genetics, 16(19), 2306–2314. PMID: 17666540

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Choose precision On time, every time!

Precision
  • 98% on time collections with a 60 minutes promise
  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

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