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Leptin deficiency (LEP) gene analysis
₹ 18500
Leptin Deficiency (LEP) Gene Analysis
₹ 18500 ₹ 18500

Leptin Deficiency (LEP) Gene Analysis

Sample Type 51+ booked in last 3 days
Precaution
Sample Type
Swab
Precaution
Fasting
Yes
Precaution
Report
Within 4 Weeks

Leptin deficiency (LEP) gene analysis Price

₹ 18500

Brief Details

Preparation
No special preparation required
Also Known As
Leptin deficiency Gene Panel by NGS
Fasting
Fasting not required
Reporting Time
After 4 weeks
Purpose
To detect pathogenic variants in the LEP gene associated with congenital leptin deficiency and related metabolic disorders

What is the Leptin Deficiency (LEP) Gene Analysis?

Leptin Deficiency (LEP) Gene Analysis is a genetic blood test used to identify inherited mutations in the LEP gene. Leptin is a hormone produced by fat cells that plays a critical role in regulating appetite, body weight, and energy balance.

Congenital leptin deficiency is a rare genetic condition that typically presents in early childhood with severe obesity, excessive hunger, and metabolic disturbances. This test uses Next Generation Sequencing technology to analyse the LEP gene and help confirm a genetic diagnosis.

What Does the Leptin Deficiency (LEP) Gene Analysis Measure?

This genetic test evaluates changes in the LEP gene to support diagnosis and management:

  • Detection of disease-causing variants in the LEP gene
  • Confirmation of congenital leptin deficiency
  • Differentiation of genetic obesity from lifestyle-related obesity
  • Support for personalised treatment planning
  • Guidance for genetic counselling and family screening

Leptin Deficiency (LEP) Gene Analysis: Who Needs It and Why It’s Done

What Symptoms May Call for Leptin Deficiency (LEP) Gene Analysis?

Doctors may recommend this test if an individual shows:

  • Severe early-onset obesity beginning in infancy or early childhood
  • Excessive appetite or constant hunger
  • Rapid weight gain despite dietary control
  • Delayed puberty or hormonal abnormalities
  • Family history of severe genetic obesity

Who Should Get Leptin Deficiency (LEP) Gene Analysis?

This test may be advised for:

  • Children with unexplained early-onset severe obesity
  • Individuals suspected of having congenital leptin deficiency
  • Patients with obesity not explained by lifestyle factors alone
  • Individuals with a family history of genetic obesity disorders
  • Couples with known genetic risk planning pregnancy

Why is Leptin Deficiency (LEP) Gene Analysis Done?

  • The test helps confirm a genetic cause of obesity, enabling targeted therapy, accurate counselling, and avoidance of ineffective lifestyle-only interventions.

Importance of Leptin Deficiency (LEP) Gene Analysis

  • Early identification of leptin deficiency is important because specific treatments, including recombinant leptin therapy, may significantly improve appetite control, weight management, and metabolic health. Genetic confirmation also supports long-term management and informed family planning decisions.

Leptin Deficiency (LEP) Gene Analysis Booking & Reports – Metropolis Healthcare

How to Book the Leptin Deficiency (LEP) Gene Analysis and Get Your Reports?

  1. Simple Online Booking
    Booking can be done through the Metropolis Healthcare website or app. Select the Leptin Deficiency (LEP) Gene Analysis, choose a convenient time slot, and opt for home sample collection or a nearby Metropolis Lab.
  2. Safe Sample Collection
    Trained phlebotomists collect blood samples while following strict safety and hygiene protocols.
  3. Sample Tracking Updates
    You receive updates at every stage, from sample collection to report generation.
  4. Accurate Laboratory Testing
    Samples are analysed at NABL and CAP accredited laboratories using advanced molecular diagnostic technology.
  5. Quick and Easy Reports
    Reports are shared via email, WhatsApp, or can be downloaded from the Metropolis Healthcare platform.

Interpreting Leptin Deficiency (LEP) Gene Analysis Results

What Your Leptin Deficiency (LEP) Gene Analysis Results May Indicate

Parameter Expected Finding Pathogenic Variant Detected May Indicate No Variant Detected May Indicate
LEP gene No disease-causing variant detected Congenital leptin deficiency affecting appetite and weight regulation Obesity may be due to other genetic or non-genetic causes

Understanding Abnormal Leptin Deficiency (LEP) Gene Analysis Results

Gene What a Pathogenic Variant May Indicate
LEP Impaired leptin production leading to severe early-onset obesity and metabolic imbalance

How Should You Prepare for Leptin Deficiency (LEP) Gene Analysis?

  • No fasting required
  • Maintain normal hydration
  • Inform your doctor about medications or supplements
  • Provide detailed clinical and family history
  • Ensure test requisition form and consent are completed

How Is the Leptin Deficiency (LEP) Gene Analysis Done?

  • Preparation: A tourniquet is applied to make veins visible
  • Cleaning: The puncture site is cleaned with antiseptic
  • Sample Collection: About 3 to 5 ml of blood is drawn into an EDTA vacutainer
  • Completion: The needle is removed and a bandage is applied
  • Processing: DNA is analysed using Next Generation Sequencing

Conditions That May Affect Leptin Deficiency (LEP) Gene Analysis Accuracy

  • Recent blood transfusion
  • Incomplete or inaccurate clinical history
  • Low-level mosaic genetic changes
  • Variants of uncertain significance requiring further evaluation

Diseases That Leptin Deficiency (LEP) Gene Analysis Can Help Detect

  • Congenital leptin deficiency
  • Genetic forms of severe early-onset obesity
  • Leptin-related metabolic and endocrine disorders

References

  1. Farooqi I.S., Jebb S.A., Langmack G., et al. (1999). Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine, 341(12), 879–884. PMID: 10486419
  2. Montague C.T., Farooqi I.S., Whitehead J.P., et al. (1997). Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature, 387(6636), 903–908. PMID: 9202122
  3. Farooqi I.S., O’Rahilly S. (2009). Leptin: a pivotal regulator of human energy homeostasis. American Journal of Clinical Nutrition, 89(3), 980S–984S. PMID: 19176737

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Choose precision On time, every time!

Precision
  • 98% on time collections with a 60 minutes promise
  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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