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Hereditary Spastic Paraplegia Gene Panel
₹ 19400
Hereditary Spastic Paraplegia Gene Panel
₹ 19400 ₹ 19400

Hereditary Spastic Paraplegia Gene Panel

Sample Type 51+ booked in last 3 days
Precaution
Sample Type
Swab
Precaution
Fasting
Yes
Precaution
Report
Within 4 Weeks

Hereditary Spastic Paraplegia Gene Panel Price

₹ 19400

Brief Details

Preparation
No special preparation required
Also Known As
Hereditary spastic paraplegia Gene Panel by NGS
Fasting
Fasting not required
Reporting Time
After 4 weeks
Purpose
To identify genetic mutations causing hereditary spastic paraplegia (HSP) and support diagnosis, management, and family counselling

What is the Hereditary Spastic Paraplegia Gene Panel?

The Hereditary Spastic Paraplegia Gene Panel is a genetic blood test designed to identify inherited causes of hereditary spastic paraplegia (HSP), a group of neurodegenerative disorders characterised by progressive stiffness and weakness of the lower limbs.

HSP can present as a pure form (primarily affecting the legs) or a complex form associated with additional neurological features such as seizures, cognitive impairment, ataxia, neuropathy, or vision problems. This test uses advanced Next Generation Sequencing technology to analyse multiple genes known to be associated with HSP.

What Does the Hereditary Spastic Paraplegia Gene Panel Measure?

This genetic test evaluates disease-causing variants linked to motor neuron and axonal degeneration:

  • Detection of pathogenic variants causing hereditary spastic paraplegia
  • Differentiation between pure and complex HSP subtypes
  • Distinction of HSP from other neurodegenerative or neuromuscular disorders
  • Support for prognosis and long-term care planning
  • Guidance for genetic counselling, family screening, and reproductive planning

Hereditary Spastic Paraplegia Gene Panel: Who Needs It and Why It’s Done

What Symptoms May Call for a Hereditary Spastic Paraplegia Gene Panel?

Doctors may recommend this test if an individual presents with:

  • Progressive stiffness and weakness of the legs
  • Difficulty walking, frequent falls, or gait abnormalities
  • Increased muscle tone or spasticity
  • Bladder dysfunction or urinary urgency
  • Associated neurological features such as ataxia, seizures, neuropathy, or cognitive decline

Who Should Get a Hereditary Spastic Paraplegia Gene Panel?

This test may be advised for:

  • Individuals with suspected hereditary spastic paraplegia
  • Patients with early-onset or unexplained progressive spasticity
  • Individuals with a family history of spastic paraplegia or related disorders
  • Patients with inconclusive imaging or electrophysiological studies
  • Couples with known genetic risk planning pregnancy

Why is the Hereditary Spastic Paraplegia Gene Panel Done?

  • The test confirms the genetic basis of hereditary spastic paraplegia, enabling accurate diagnosis, avoidance of unnecessary investigations, appropriate management, and informed family counselling.

Importance of the Hereditary Spastic Paraplegia Gene Panel

  • Hereditary spastic paraplegia shows wide clinical and genetic diversity. Identifying the underlying gene mutation helps clinicians predict disease course, tailor supportive therapy, guide rehabilitation strategies, and counsel families regarding inheritance patterns and recurrence risks. Early genetic confirmation also assists in differentiating HSP from treatable or reversible neurological conditions.

Hereditary Spastic Paraplegia Gene Panel Booking & Reports – Metropolis Healthcare

How to Book the Hereditary Spastic Paraplegia Gene Panel and Get Your Reports?

  1. Simple Online Booking
    Book through the Metropolis Healthcare website or mobile app. Choose the Hereditary Spastic Paraplegia Gene Panel, select a convenient slot, and opt for home collection or lab visit.
  2. Safe Sample Collection
    Blood samples are collected by trained professionals using strict safety and hygiene protocols.
  3. Sample Tracking Updates
    Receive regular updates from sample collection to report generation.
  4. Advanced Laboratory Testing
    Testing is performed at NABL and CAP accredited laboratories using state-of-the-art molecular diagnostics.
  5. Easy Access to Reports
    Reports are delivered via email, WhatsApp, or downloadable from the Metropolis platform.

Interpreting Hereditary Spastic Paraplegia Gene Panel Results

What Your Hereditary Spastic Paraplegia Gene Panel Results May Indicate

Parameter Expected Finding Pathogenic Variant Detected May Indicate No Variant Detected May Indicate
HSP-related genes No disease-causing variant detected Hereditary spastic paraplegia or related neurodegenerative disorder Symptoms may be due to other genetic or acquired neurological conditions

Understanding Abnormal Hereditary Spastic Paraplegia Gene Panel Results

Gene Group What a Pathogenic Variant May Indicate
SPAST, ATL1, SPG11, SPG7 Common genetic causes of pure or complex HSP
KIF1A, KIF5A, REEP genes Axonal transport and motor neuron dysfunction
FA2H, PNPLA6, CYP7B1 Complex HSP with metabolic or neurodegenerative features

How Should You Prepare for a Hereditary Spastic Paraplegia Gene Panel?

  • No fasting required
  • Maintain normal hydration
  • Inform your clinician about medications or supplements
  • Provide detailed clinical and family history
  • Ensure test requisition form and consent are completed

How Is the Hereditary Spastic Paraplegia Gene Panel Done?

  • Preparation: A tourniquet is applied to identify a vein
  • Cleaning: The site is cleaned with antiseptic
  • Sample Collection: 3–5 ml of blood is collected into an EDTA vacutainer
  • Completion: Bandage applied after needle removal
  • Analysis: DNA is analysed using Next Generation Sequencing

Conditions That May Affect Test Accuracy

  • Recent blood transfusion
  • Incomplete clinical history
  • Low-level mosaic variants
  • Variants of uncertain significance requiring further evaluation

Diseases That the Hereditary Spastic Paraplegia Gene Panel Can Help Detect

  • Pure hereditary spastic paraplegia
  • Complex hereditary spastic paraplegia
  • Overlapping neurodegenerative and motor neuron disorders

References

  1. Fink J.K. (2013). Hereditary spastic paraplegia clinical principles and genetic advances. Seminars in Neurology, 33(3), 293–305. PMID: 24072569
  2. Blackstone C. (2018). Hereditary spastic paraplegia genes and mechanisms. Neurobiology of Disease, 109, 59–67. PMID: 28756231
  3. Depienne C., Stevanin G., Brice A., et al. (2007). Hereditary spastic paraplegias an update. Journal of Neurology, 254(5), 523–534. PMID: 17530490

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Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

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  • Real-time tracking of phlebotomist arrival and report generation
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  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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