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Monogenic and syndromic obesity gene panel
₹ 19400
Monogenic and Syndromic Obesity Gene Panel
₹ 19400 ₹ 19400

Monogenic and Syndromic Obesity Gene Panel

Sample Type 51+ booked in last 3 days
Precaution
Sample Type
Swab
Precaution
Fasting
Yes
Precaution
Report
Within 4 Weeks

Monogenic and syndromic obesity gene panel Price

₹ 19400

Brief Details

Preparation
No specific preparation required
Also Known As
Monogenic and syndromic obesity gene panel by NGS
Fasting
Fasting not required
Reporting Time
After 4 weeks
Purpose
To identify genetic causes of early-onset and syndromic obesity

What Is the Monogenic and Syndromic Obesity Gene Panel?

The Monogenic and Syndromic Obesity Gene Panel is an advanced genetic test performed on an EDTA blood sample. It analyses a group of genes known to play a role in inherited forms of obesity.

This test helps determine whether obesity is caused by specific genetic changes rather than lifestyle or environmental factors alone. It is particularly useful in individuals with early-onset, severe, or syndromic obesity, where excess weight may be associated with developmental, hormonal, or physical features.

What Does the Monogenic and Syndromic Obesity Gene Panel Measure?

This test examines genes involved in appetite control, energy balance, metabolism, and hormonal regulation:

  • Detects disease-causing genetic variants linked to monogenic and syndromic obesity
  • Helps differentiate genetic obesity from lifestyle-related weight gain
  • Supports personalised treatment and long-term obesity management
  • Assists genetic counselling for affected individuals and families
  • Provides insights for future health and family planning

Monogenic and Syndromic Obesity Gene Panel: Who Needs It and Why It’s Done

What Symptoms May Call for a Monogenic and Syndromic Obesity Gene Panel?

Doctors may recommend this test when obesity presents with unusual patterns or additional features:

  • Rapid weight gain beginning in early childhood
  • Severe obesity that does not improve with diet or physical activity
  • Excessive hunger or abnormal eating behaviour
  • Developmental delay or learning difficulties
  • Physical features suggesting a genetic syndrome

Who Should Get a Monogenic and Syndromic Obesity Gene Panel?

This test may be advised for:

  • Children or adults with early-onset severe obesity
  • Individuals with obesity and developmental, neurological, or hormonal abnormalities
  • Families with a known history of inherited obesity disorders
  • Patients undergoing evaluation by endocrinologists or genetic specialists
  • Individuals needing confirmation of a genetic diagnosis

Why Is the Monogenic and Syndromic Obesity Gene Panel Done?

The test helps confirm a genetic cause of obesity, allowing accurate diagnosis, appropriate treatment planning, and informed counselling for patients and their families.

Importance of the Monogenic and Syndromic Obesity Gene Panel

This gene panel is important for understanding complex obesity cases that cannot be explained by lifestyle factors alone. Identifying a genetic cause helps avoid unnecessary treatments, supports targeted medical care, and provides clarity about long-term health risks and inheritance patterns.

Monogenic and Syndromic Obesity Gene Panel Booking & Reports – Metropolis Healthcare

How to Book the Monogenic and Syndromic Obesity Gene Panel and Get Your Reports?

  1. Simple Online Booking
    Booking can be done through the Metropolis Healthcare App or website. Select the Monogenic and Syndromic Obesity Gene Panel, choose a convenient time slot, and provide your address for a blood test at home. You may also visit a nearby Metropolis Lab if you prefer in person sample collection.
  2. Safe Home Sample Collection
    Trained phlebotomists collect your blood sample while strictly following safety and hygiene protocols.
  3. Sample Tracking Updates
    You receive updates at every stage, from sample collection to testing, through the Metropolis Healthcare platform.
  4. Accurate Laboratory Testing
    Your sample is processed at NABL and CAP accredited laboratories using advanced next generation sequencing technology.
  5. Quick and Easy Reports
    Your reports are shared via email, WhatsApp, or can be downloaded from the Metropolis Healthcare website or app.

Is Home Sample Collection for the Monogenic and Syndromic Obesity Gene Panel Available Near You?

Yes, Metropolis Healthcare offers home sample collection for the Monogenic and Syndromic Obesity Gene Panel. This service saves you time, reduces the need for travel, and ensures professional sample handling while maintaining strict quality standards.

How Long Does It Take to Get the Monogenic and Syndromic Obesity Gene Panel Report?

Reports are usually available after 4 weeks once the sample reaches the lab.
Note: Reporting time may vary based on your location.

Where Can I See or Get Monogenic and Syndromic Obesity Gene Panel Results?

You can access your test results through the Metropolis Healthcare website or mobile app by logging in with your credentials. Reports are also shared via email or WhatsApp, and you may collect a physical copy from the Metropolis Lab if required.

Interpreting Monogenic and Syndromic Obesity Gene Panel Results

What Your Monogenic and Syndromic Obesity Gene Panel Results May Indicate

Parameter Expected Finding Pathogenic Variant Detected May Indicate No Variant Detected May Indicate
Obesity-related genes in the panel No disease-causing variant detected A confirmed genetic cause of monogenic or syndromic obesity affecting appetite regulation, metabolism, or energy balance Obesity may be due to other genetic factors not covered in the panel or environmental and lifestyle influences

Understanding Abnormal Monogenic and Syndromic Obesity Gene Panel Results

Gene Group What a Pathogenic Variant May Indicate
Appetite regulation genes such as LEP, LEPR, MC4R, POMC Disrupted appetite control leading to severe hunger and early-onset obesity
Syndromic obesity genes such as BBS genes, ALMS1, MAGEL2 Obesity associated with developmental, neurological, visual, or physical abnormalities
Metabolic and endocrine genes Altered energy balance, hormonal signalling, or metabolic dysfunction contributing to obesity

How Should You Prepare for a Monogenic and Syndromic Obesity Gene Panel?

This test requires minimal preparation. Follow these simple instructions:

  • No fasting required: You can eat and drink normally before the test
  • Normal hydration: Drink water as you usually do
  • Medication disclosure: Inform your doctor about all medicines or supplements you are taking
  • Clinical documentation: Ensure the test requisition form and clinical history are provided, as they are mandatory
  • Stay relaxed: No special physical preparation is needed

How Is a Monogenic and Syndromic Obesity Gene Panel Done? (Step-by-Step Procedure)

The test is performed using a simple blood collection process:

  • Preparation: A tourniquet is tied around your arm to make veins more visible
  • Cleaning: The puncture site is cleaned with antiseptic
  • Sample Collection: A sterile needle is used to draw about 3 to 5 ml of blood into an EDTA vacutainer
  • Completion: The needle is removed, and a bandage is applied
  • Processing: The sample undergoes next generation sequencing to analyse obesity-related genes

Conditions That May Affect Monogenic and Syndromic Obesity Gene Panel Accuracy

Certain patient-related factors may influence test interpretation:

  • Incomplete or missing clinical history can limit accurate interpretation
  • Recent blood transfusions may affect genetic analysis
  • Mosaic genetic changes may be harder to detect
  • Variants of uncertain significance may require follow-up testing or clinical correlation

Diseases That the Monogenic and Syndromic Obesity Gene Panel Can Help Detect

  • Monogenic obesity disorders
  • Syndromic obesity conditions such as Bardet-Biedl syndrome and Alström syndrome
  • Genetic leptin pathway disorders
  • Inherited metabolic and endocrine dysfunctions
  • Rare genetic obesity-related developmental syndromes

References

  1. Dubern B., Clément K. (2012). Leptin and leptin receptor related monogenic obesity. Biochimie, 94(10), 2111–2115. PMID: 22705502
  2. Farooqi I.S., O’Rahilly S. (2006). Genetics of obesity in humans. Endocrine Reviews, 27(7), 710–718. PMID: 17122358
  3. Huvenne H., Dubern B., Clément K., Poitou C. (2016). Rare genetic forms of obesity: clinical approach and current treatments in children and adults. The Lancet Diabetes & Endocrinology, 4(10), 832–842. PMID: 27498394
  4. van der Klaauw A.A., Farooqi I.S. (2015). The hunger genes: pathways to obesity. Cell, 161(1), 119–132. PMID: 25815990

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

Regular exercise, a balanced diet, avoiding smoking, maintaining a healthy weight, and managing stress all help reduce heart disease risk.

Common signs include irritability, trouble sleeping, headaches, difficulty concentrating, and muscle tension.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

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Precision
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  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

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