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Autoimmune Liver Disease Profile 4 Test
₹ 5,725
Autoimmune Liver Disease Profile 4 Test
₹ 5,725
51+ booked in last 3 days

Autoimmune Liver Disease Profile 4 Test

Also Known As :

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Report after 2 days 08:00 pm
Fasting
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Recommended for
Recommended for Male, Female
Autoimmune Liver Disease Profile - 4
₹ 5,725

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Includes AMA M2, M2-3E (Bpo), Sp100, PML, gp210, LKM1, LC1, SLA / LP, Ro52.

Autoimmune liver disease refers to a group of disorders in which the immune system mistakenly attacks the liver. This results in inflammation and damage to the liver cells, leading to various degrees of liver injury. There are several types of autoimmune liver disease, the most common types are:

  • Autoimmune hepatitis (AIH): It is characterized by inflammation and destruction of liver cells, resulting in cirrhosis, jaundice, fatigue, abdominal pain and itchy skin.
  • Primary biliary cholangitis (PBC): it is a chronic disease characterized by inflammation and damage of the small bile ducts within the liver. This results in the obstruction of bile flow and eventually leads to cirrhosis, jaundice and itching.
  • Primary sclerosing cholangitis (PSC): It is characterized by inflammation and scarring of the bile ducts, both inside and outside the liver, leading to bile duct obstruction, which can result in cirrhosis, jaundice, and itching.

The Autoimmune Liver Disease Profile 4 Test is a comprehensive blood test designed to detect the presence of specific autoantibodies associated with various autoimmune liver diseases. This test helps doctors diagnose and differentiate between conditions such as primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). By identifying these autoantibodies, the test provides valuable insights into the patient's liver health and immune system function.

The Autoimmune Liver Disease Profile 4 Test includes tests for AMA M2, M2-3E (Bpo), Sp100, PML, gp210, LKM1, LC1, SLA/LP, and Ro52 antibodies. These autoantibodies are specific markers for different types of autoimmune liver diseases, and their presence can help determine the appropriate course of treatment. This test is particularly useful for individuals experiencing symptoms such as abdominal pain, jaundice, itchy skin, and fatigue, which could indicate the presence of an autoimmune liver condition.

Written by : Supriya Kulkarni, Lead-Content & Training
 

Reasons for Undergoing the Autoimmune Liver Disease Profile 4 Test

There are several reasons why your doctor may recommend the Autoimmune Liver Disease Profile 4 Test:

  • Diagnosing Autoimmune Liver Diseases: If you are experiencing symptoms such as abdominal pain, jaundice, itchy skin, or fatigue, this test can help determine if an autoimmune liver disease is the underlying cause.
  • Distinguishing Between Autoimmune Liver Conditions: The test helps differentiate between various autoimmune liver diseases, such as AIH and PBC, allowing for a more targeted treatment approach.
  • Monitoring Disease Progression: If you have been diagnosed with an autoimmune liver disease, regular testing can help monitor the progression of the condition and assess the effectiveness of treatment.
  • Ruling Out Other Liver Conditions: By identifying specific autoantibodies, the test can help rule out other liver conditions that may present with similar symptoms.

List of Parameters Considered During the Autoimmune Liver Disease Profile 4 Test

The Autoimmune Liver Disease Profile 4 Test measures several autoantibodies associated with specific autoimmune liver diseases:

  • AMA M2: Indicates the presence of antimitochondrial antibodies, which are specific for primary biliary cholangitis (PBC).
  • M2-3E (Bpo): Associated with the M2-3E isoform of PBC.
  • Sp100: Indicates antibodies against the Sp100 protein, which are associated with PBC.
  • PML: Indicates antibodies against the PML protein, which are associated with PBC.
  • gp210: Indicates antibodies against the gp210 protein, which are associated with PBC.
  • LKM1: Indicates the presence of anti-liver kidney microsomal antibodies type 1, which are associated with autoimmune hepatitis type 2 (AIH-2).
  • LC1: Indicates the presence of antibodies against the LC1 protein, which are associated with AIH-2.
  • SLA/LP: Indicates the presence of antibodies against the SLA/LP protein, which are associated with AIH.
  • Ro52: Although not exclusively specific to liver diseases, it can be part of the autoimmune profile.

Autoimmune Liver Disease Profile 4 Test Preparation

To prepare for the Autoimmune Liver Disease Profile 4 Test, follow these steps:

  • Fasting: A 12- to 14-hour fasting period is required before the test. Avoid eating or drinking anything except water during this time.
  • Blood Sample Collection: A phlebotomist will collect a blood sample from a vein, usually in your arm. A tourniquet will be placed on your upper arm, and the skin will be disinfected before the needle is inserted.

Autoimmune Liver Disease Profile 4 Test Results & Interpretation

The results of the Autoimmune Liver Disease Profile 4 Test are interpreted based on the presence and levels of the autoantibodies:

  • Positive Results: Indicate the presence of specific autoantibodies associated with autoimmune liver diseases. For example, positive AMA M2 suggests PBC, while positive LKM1 and LC1 indicate AIH type 2.
  • Negative Results: Suggest the absence of these specific autoantibodies, but do not entirely rule out autoimmune liver diseases, as some tests can have false negatives.

Home Collection for Autoimmune Liver Disease Profile 4 Test Near You

Metropolis Healthcare offers a convenient home sample collection service for the Autoimmune Liver Disease Profile 4 Test. A trained phlebotomist will visit your residence to collect the blood sample, ensuring your comfort and safety while maintaining high standards of sample handling and testing accuracy. This service allows you to receive timely and reliable results without compromising on the quality of the diagnostic solution. By opting for Metropolis Healthcare's home collection option, you can benefit from their commitment to making healthcare accessible and providing quality diagnostic services conveniently at your doorstep.

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

  • An autoimmune liver disease profile-4 that includes AMA M2, M2-3E (Bpo), Sp100, PML, gp210, LKM1, LC1, SLA/LP, and Ro52 tests is done to detect the presence of specific antibodies that are associated with different subtypes of autoimmune liver disease.
  • The presence of these antibodies can help healthcare providers to make a more specific diagnosis of a particular subtype of autoimmune liver disease and to monitor the progression of the disease over time.

You should get the Autoimmune Liver Disease Profile -4 done if you observe the following symptoms:

  • Abdominal pain
  • Jaundice
  • Itchy skin
  • Fatigue

  • Patient Preparation: 12-14 hrs fasting required 

    Total Tests Included: 9 (AMA M2, M2-3E (Bpo), Sp100, PML, gp210, LKM1, LC1, SLA / LP, Ro52)

The Autoimmune Liver Disease Profile-4 measures the autoantibodies AMA M2, M2-3E (Bpo), Sp100, PML, gp210, LKM1, LC1, SLA / LP, Ro52.

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

When AMA M2, M2-3E (Bpo), Sp100, PML, gp210, LKM1, LC1, SLA/LP, and Ro52 tests are positive in a patient, it indicates the presence of specific antibodies that are associated with different subtypes of autoimmune liver disease.

  • A positive AMA M2 test indicates the presence of antimitochondrial antibodies (AMA), which are specific for primary biliary cirrhosis (PBC).
  • A positive M2-3E (Bpo) test indicates the presence of antibodies specific to the M2-3E isoform of PBC.
  • A positive Sp100 test indicates the presence of antibodies specific to the Sp100 protein, which is associated with PBC.
  • A positive PML test indicates the presence of antibodies specific to the PML protein, which is associated with PBC.
  • A positive gp210 test indicates the presence of antibodies specific to the gp210 protein, which is associated with PBC.
  • A positive LKM1 test indicates the presence of antibodies specific to the LKM1 protein, which is associated with autoimmune hepatitis type 2 (AIH-2).
  • A positive LC1 test indicates the presence of antibodies specific to the LC1 protein, which is associated with AIH-2.
  • A positive SLA/LP test indicates the presence of antibodies specific to the SLA/LP protein, which is associated with PBC.
  • A positive Ro52 test indicates the presence of antibodies specific to the Ro52 protein, which is associated with PBC.

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