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NextGen Colocore Panel by NGS, FFPE Tissue**
₹ 16000
Next Gen Colocore Panel
₹ 16000 ₹ 16000

Next Gen Colocore Panel

Sample Type 51+ booked in last 3 days
Precaution
Report
Within 4 Weeks

NextGen Colocore Panel by NGS, FFPE Tissue** Price

₹ 16000

Brief Details

Preparation
Clinical history is mandatory.
Also Known As
NextGen Colocore Panel by NGS, coloCORE targeted panel
Fasting
Not required
Reporting Time
After 20 days
Purpose
Detects mutations in the RAS gene family, useful for diagnosing and managing colorectal and pancreatic cancers, and helps in predicting response to targeted therapies.

What Is a NextGen ColoCore Panel? 

The NextGen ColoCore Panel is an advanced genetic test that uses next-generation sequencing (NGS) technology to examine your tumour tissue. This specialised test analyses seven key genes that are commonly altered in colorectal tumours. The test helps detect specific genetic mutations in colorectal cancer tissue, guiding your doctor towards the most effective treatment options for your health condition. 

What Does the NextGen ColoCore Panel Measure? 

This comprehensive panel measures several important aspects of your tumour's genetic makeup: 

  • Gene mutations: It identifies changes in genes like KRAS, NRAS, and BRAF that affect how cancer cells grow.
    • Treatment response markers: It detects mutations that predict how well you might respond to targeted therapies.
    • Lynch syndrome indicators: It helps rule out hereditary colorectal cancer syndromes. 
    • Rare gene fusions: It covers NTRK gene fusions that occur in a small percentage of colorectal cancers. 
    • Therapy resistance markers: Identifies genetic changes that may affect treatment effectiveness. 
    • Personalised treatment guidance: Provides information for tailored cancer care strategies. 

NextGen ColoCore Panel: Who Needs It and Why It's Done 

What Symptoms May Call for a NextGen ColoCore Panel? 

While this NGS sequencing test doesn't diagnose symptoms directly, certain clinical situations may prompt your doctor to recommend genetic testing of your tumour: 

  • Diagnosis of advanced or metastatic colorectal cancer requiring treatment planning.
    • Need to determine the best targeted therapy options for your specific tumour.
    • Family history suggesting possible hereditary colorectal cancer syndromes. 
    • Tumour characteristics that suggest genetic alterations may be present. 
    • Planning for personalised cancer treatment based on your tumour's genetic profile. 

Who Should Get a NextGen ColoCore Panel? 

Several groups of patients may benefit from this specialised genetic test: 

  • Patients with advanced colorectal cancer: Those with metastatic disease who need targeted therapy guidance.
    • Young cancer patients: Individuals diagnosed with colorectal cancer at an unusually young age.
    • Patients with a strong family history: Those with multiple relatives affected by colorectal or related cancers. 
    • Treatment planning candidates: Patients whose doctors need genetic information to choose the most effective therapy. 
    • Hereditary syndrome suspects: Individuals whose cancer pattern suggests an inherited genetic cause. 

Why Is a NextGen ColoCore Panel Done? 

The NextGen ColoCore Panel is performed to create a personalised treatment plan based on your tumour's unique genetic profile. This helps your doctor select the most effective targeted therapies for your specific type of colorectal cancer. 

Importance of a NextGen ColoCore Panel 

The NextGen ColoCore Panel plays a vital role in modern cancer care by enabling precision medicine approaches. This test identifies specific genetic alterations that can predict how well certain treatments will work, helping doctors select targeted therapies that are most likely to be effective for your individual cancer. The genetic information also helps rule out Lynch syndrome, an important hereditary condition that affects cancer risk and treatment decisions.  

By understanding your tumour's genetic profile, your healthcare team can avoid ineffective treatments, reduce unnecessary side effects, and focus on therapies with the highest chance of success. This personalised approach to cancer treatment represents a significant advancement in colorectal cancer care, offering hope for better outcomes and improved quality of life. 

NextGen ColoCore Panel Booking & Reports – Metropolis Healthcare India 

How to Book a NextGen ColoCore Panel? 

  1. Simple Online Booking 
    Booking can be done through the Metropolis Healthcare App or website. Select the 'NextGen ColoCore Panel', choose a convenient time slot, and visit the nearest Metropolis Lab. 
     
  2. Sample Tracking Updates 
    Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. 
     
  3. Accurate Laboratory Testing 
    Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 
     
  4. Quick & Easy Reports 
    Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is Home Sample Collection for the NextGen ColoCore Panel Available Near You? 

No, Metropolis Healthcare does not provide home sample collection for the NextGen ColoCore Panel. This test requires a tissue sample from your tumour, which is typically collected during surgery or biopsy at a hospital. We maintain the highest standards of accuracy and reliability, with NABL and CAP accredited laboratories processing your sample with precision and care. 

How Long Does It Take to Get a NextGen ColoCore Panel Report? 

Reports are usually available within 20 days once the sample reaches the lab. 

Note: Reporting time may vary depending on your location. 

Where Can I See or Get NextGen ColoCore Panel Results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting NextGen ColoCore Panel Results 

The following table shows how your NextGen ColoCore Panel results are interpreted and what different findings mean for your treatment: 

Gene/Parameter 

Result Type 

Clinical Significance 

KRAS 

Mutation Detected (e.g., p.G12V) 

Pathogenic variant; may affect response to certain targeted therapies 

NRAS 

Mutation Detected 

Influences treatment selection for targeted therapies 

BRAF 

Mutation Detected 

Important for prognosis and treatment planning 

ERBB2 

Amplification Detected 

May indicate suitability for HER2-targeted therapies 

TP53 

Mutation Detected 

Common tumour suppressor gene alteration in colorectal cancer 

PIK3CA 

Mutation Detected 

May influence response to PI3K pathway inhibitors 

NTRK (1, 2, 3) 

Fusion Detected 

Rare but actionable for NTRK inhibitor therapy 

Conditions that May Affect NextGen ColoCore Panel Accuracy 

Several factors related to your tissue sample can influence the accuracy of your NextGen ColoCore Panel results: 

  • Sample quality: Poorly preserved or inadequately fixed tissue may not yield reliable results.
    • Tumour content: Samples with insufficient tumour cells may not provide accurate genetic information.
    • Sample age: Very old tissue blocks may have degraded DNA, affecting test performance. 
    • Previous treatments: Chemotherapy or radiation before surgery might alter the genetic profile of tumour cells. 
    • Sample contamination: The presence of normal tissue mixed with tumour tissue can dilute mutation detection. 
    • Storage conditions: Improper storage temperature or handling can affect DNA quality. 

How Is a NextGen ColoCore Panel Done? 

The NextGen ColoCore Panel follows a systematic laboratory process to analyse your tumour genetics: 

  • Tissue preparation: Your formalin-fixed paraffin-embedded tissue block is processed to extract DNA.
    • Quality assessment: Laboratory technicians verify that the sample contains sufficient tumour cells and good-quality DNA.
    • DNA extraction: Genetic material is carefully extracted from the tumour tissue. 
    • Library preparation: The DNA is prepared for sequencing by targeting the seven specific genes in the panel. 
    • Next-generation sequencing: Advanced sequencing technology reads the genetic code of the targeted genes. 
    • Data analysis: Sophisticated software analyses the genetic data to identify mutations and variants. 
    • Report generation: Expert pathologists review the findings and create a comprehensive report with treatment recommendations. 

How Should You Prepare for a NextGen ColoCore Panel? 

Preparing for this test involves coordination with your healthcare team: 

  • No special dietary preparation: You don't need to change your eating habits before tissue collection.
    • Provide complete clinical history: Share detailed information about your cancer diagnosis and family history.
    • Continue regular medications: Take your prescribed medicines as usual unless your doctor advises otherwise. 
    • Coordinate with your surgeon: Ensure proper tissue collection and handling during your biopsy or surgery. 
    • Discuss timing: Plan the test timing with your oncologist to align with treatment decisions. 

Diseases that a NextGen ColoCore Panel Can Help Detect 

This genetic test can help identify and manage several important health conditions: 

  • Colorectal cancer: Primary focus for genetic profiling and treatment guidance
    • Lynch syndrome: Hereditary cancer syndrome affecting multiple organs
    • Familial adenomatous polyposis: Inherited condition causing multiple colon polyps 

NextGen ColoCore Panel/Packages that You Can Book With Metropolis Healthcare 

Here are related tests available at Metropolis Healthcare that complement the NextGen ColoCore Panel for comprehensive cancer assessment: 

Test/Package Name 

Purpose/Highlights 

Tumour/Cancer Marker Profile Test 

Measures blood proteins that indicate cancer activity 

Microsatellite Instability (MSI)/HNPCC/Lynch Syndrome, PCR 

Specific tests for hereditary colorectal cancer syndromes 

RAS Extended Panel (KRAS, BRAF, NRAS, PIK3CA) Test 

Broader genetic analysis for treatment planning 

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Choose precision On time, every time!

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  • Real-time tracking of phlebotomist arrival and report generation
  • Fully digital report delivery—view from mobile or desktop instantly
  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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About Us

Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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