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Alexander disease (GFAP) gene analysis
₹ 18500
Alexander Disease (GFAP) Gene Analysis Test
₹ 18500 ₹ 18500

Alexander Disease (GFAP) Gene Analysis Test

Sample Type 51+ booked in last 3 days
Precaution
Sample Type
Swab
Precaution
Fasting
Yes
Precaution
Report
Within 4 Weeks

Alexander disease (GFAP) gene analysis Price

₹ 18500

Brief Details

Preparation
No special preparation required
Also Known As
Alexander disease gene analysis
Fasting
Fasting not required
Reporting Time
After 4 weeks
Purpose
To detect genetic mutations causing Alexander disease, a rare neurodegenerative leukodystrophy

What is the Alexander Disease (GFAP) Gene Analysis Test?

The Alexander Disease (GFAP) Gene Analysis Test is a genetic blood test used to diagnose Alexander disease, a rare disorder of the central nervous system characterised by progressive damage to the white matter of the brain.

The condition is caused by mutations in the GFAP gene, which plays a key role in maintaining normal function of astrocytes in the brain. This test uses next generation sequencing technology to identify disease causing genetic changes, helping confirm diagnosis and support long term care planning. The test requires a blood sample collected in an EDTA tube.

What Does the Alexander Disease (GFAP) Gene Analysis Test Measure?

This genetic test looks for disease causing changes in the GFAP gene:

  • Detects pathogenic variants responsible for Alexander disease
  • Helps confirm the diagnosis of leukodystrophy
  • Supports early diagnosis in infants, children, or adults
  • Aids genetic counselling and family screening
  • Assists clinicians in prognosis assessment and care planning

Alexander Disease (GFAP) Gene Analysis Test: Who Needs It and Why It’s Done

What Symptoms May Call for an Alexander Disease (GFAP) Gene Analysis Test?

Doctors may recommend this test if an individual shows:

  • Developmental delay or regression
  • Progressive neurological deterioration
  • Seizures or abnormal muscle tone
  • Enlarged head size in infants
  • MRI findings suggestive of leukodystrophy

Who Should Get an Alexander Disease (GFAP) Gene Analysis Test?

This test may be advised for:

  • Infants or children with suspected leukodystrophy
  • Individuals with unexplained progressive neurological symptoms
  • Patients with MRI features suggestive of Alexander disease
  • Families with a history of Alexander disease
  • Individuals requiring genetic confirmation for management planning

Why is the Alexander Disease (GFAP) Gene Analysis Test Done?

The test helps confirm the genetic cause of Alexander disease, allowing accurate diagnosis, informed prognosis, and appropriate supportive care and genetic counselling.

Alexander Disease (GFAP) Gene Analysis Test Booking & Reports – Metropolis Healthcare

How to Book the Alexander Disease (GFAP) Gene Analysis Test and Get Your Reports?

  1. Simple Online Booking
    Booking can be done through the Metropolis Healthcare App or website. Select the Alexander Disease (GFAP) Gene Analysis Test, choose a convenient time slot, and provide your address for a blood test at home. You may also visit a nearby Metropolis Lab if you prefer in person sample collection.
  2. Safe Home Sample Collection
    Trained phlebotomists collect your blood sample while strictly following safety and hygiene protocols.
  3. Sample Tracking Updates
    You receive updates at every stage, from sample collection to testing, through the Metropolis Healthcare platform.
  4. Accurate Laboratory Testing
    Your sample is processed at NABL and CAP accredited laboratories using advanced molecular diagnostic technology.
  5. Quick and Easy Reports
    Your reports are shared via email, WhatsApp, or can be downloaded from the Metropolis Healthcare website or app.

Is Home Sample Collection for Alexander Disease (GFAP) Gene Analysis Test Available Near You?

Yes, Metropolis Healthcare offers home sample collection for the Alexander Disease (GFAP) Gene Analysis Test. This service saves you time, reduces the need for travel, and ensures professional sample handling while maintaining strict quality standards.

In How Much Time Will I Get the Alexander Disease (GFAP) Gene Analysis Test Report?

Reports are usually available after 4 weeks once the sample reaches the lab.
Note: Reporting time may vary based on your location.

Where Can I See or Get Alexander Disease (GFAP) Gene Analysis Test Results?

You can access your test reports through the Metropolis Healthcare website or mobile app using your login credentials. Reports are also sent via email or WhatsApp, and you may collect a physical copy from the Metropolis Lab if required.

Interpreting Alexander Disease (GFAP) Gene Analysis Test Results

What Your Alexander Disease (GFAP) Gene Analysis Results May Indicate

Parameter Expected Finding Pathogenic Variant Detected May Indicate No Variant Detected May Indicate
GFAP gene No disease causing variant detected Confirmed Alexander disease Symptoms may be due to other leukodystrophies or variants not detected by this analysis

Understanding Abnormal Alexander Disease (GFAP) Gene Analysis Results

Finding What It May Indicate
Pathogenic GFAP variant Alexander disease with associated neurological progression
No pathogenic variant Alternative neurodegenerative or metabolic disorder

How Should You Prepare for an Alexander Disease (GFAP) Gene Analysis Test?

This genetic test requires minimal preparation from your side:

  • No fasting required: You can eat and drink normally before sample collection
  • Normal hydration: Maintain your usual fluid intake
  • Medication disclosure: Inform your doctor about any medicines or supplements
  • Share clinical history: Provide relevant neurological and family history
  • Consent and documentation: Ensure the test requisition form and clinical details are completed

How Is an Alexander Disease (GFAP) Gene Analysis Test Done? (Step-by-Step Procedure)

The test is performed using a standard blood collection process:

  • Preparation: A tourniquet is tied around your arm to make veins more visible
  • Cleaning: The puncture site is cleaned with antiseptic
  • Sample Collection: A sterile needle is used to draw about 3 to 5 ml of blood into an EDTA vacutainer
  • Completion: The needle is removed, and a bandage is applied
  • Processing: The sample undergoes next generation sequencing to analyse the GFAP gene

Conditions That May Affect Alexander Disease (GFAP) Gene Analysis Test Accuracy

Certain patient related factors may influence test interpretation:

  • Recent blood transfusion, which may affect genetic analysis
  • Incomplete or inaccurate clinical history
  • Presence of mosaic genetic changes requiring clinical correlation

Diseases That the Alexander Disease (GFAP) Gene Analysis Test Can Help Detect

  • Alexander disease
  • Genetic leukodystrophies
  • Inherited neurodegenerative disorders

References

  1. Li R., Johnson A.B., Salomons G., et al. (2005). Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease. Annals of Neurology, 57(3), 310–326. PMID: 15732116
  2. Namekawa M., Takiyama Y., Honda J., et al. (2002). Clinical and genetic study of Alexander disease. Neurology, 59(9), 1356–1362. PMID: 12427886
  3. Prust M., Wang J., Morizono H., et al. (2011). GFAP mutations, age at onset, and clinical subtypes in Alexander disease. Neurology, 77(13), 1287–1294. PMID: 21917772

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

Regular exercise, a balanced diet, avoiding smoking, maintaining a healthy weight, and managing stress all help reduce heart disease risk.

Common signs include irritability, trouble sleeping, headaches, difficulty concentrating, and muscle tension.

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

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  • Continuous monitoring of turnaround times to ensure accuracy and speed
  • Dedicated support team to resolve any delays or queries quickly

Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

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