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What is LCMS?
LCMS (Liquid Chromatography–Mass Spectrometry) is an advanced analytical technique combining liquid chromatography separation with mass spectrometry detection. It provides precise identification and quantification of compounds in complex biological samples.
Uses of LCMS
LCMS delivers precise analysis of complex samples, essential for modern diagnostics and research.
Detecting Vitamin and Mineral Deficiencies
LCMS provides precise detection of essential nutrients like Vitamin D, B12, and trace elements. This ensures early diagnosis of deficiencies affecting energy, immunity, and bone health.
Drug and Metabolite Monitoring
Tracks therapeutic drug levels and metabolites in the bloodstream for effective dosage and toxicity prevention. Often used in post-treatment monitoring or chronic condition management.
Research on Biomarkers for Women’s Health
Supports advanced research by identifying and quantifying biomarkers linked to conditions such as PCOS, osteoporosis, and cardiovascular risk in women.
Methodology
Liquid Chromatography–Mass Spectrometry (LCMS) is a two-step analytical technique that combines separation and detection for highly accurate results. In the first stage, liquid chromatography separates complex biological samples into individual components based on their chemical properties. These isolated compounds are then analyzed by mass spectrometry, which identifies and quantifies them with exceptional precision.
Sample Preparation
Biological samples (e.g., blood, serum, urine) are collected and processed to remove impurities.
Proper preparation ensures reliable and reproducible results.
Liquid Chromatography (LC) Separation
LC separates compounds based on chemical properties like polarity or size.
This step isolates individual components from complex mixtures.
Mass Spectrometry (MS) Detection
MS measures the mass-to-charge ratio of the separated compounds.
Provides molecular identification and quantification with extreme sensitivity.
Data Analysis & Reporting
Advanced software interprets the data, generating clear visualizations and reports.
Supports clinical decision-making with accurate, actionable insights.
Tests Performed
Essential tests for key hormones, vitamins, and minerals to guide accurate health insights.
Hormone Panels
Evaluates key reproductive hormones to detect imbalances affecting fertility, menstrual cycles, and overall women’s health.
Vitamin D & B12 Testing
Measures essential vitamins crucial for bone strength, energy levels, and nerve function to prevent deficiencies.
Metabolite Profiling for PCOS
Analyzes metabolic markers to identify hormonal and insulin-related irregularities linked to polycystic ovary syndrome.
Trace Elements (Iron, Zinc)
Assesses vital minerals that support immunity, oxygen transport, and cellular health for overall body function.
Clinical Rationale
LCMS plays a vital role in delivering precise and reliable diagnostics for women’s health. By combining high sensitivity with robust specificity, it enables early detection of hormonal imbalances, nutrient deficiencies, and metabolic disorders that may otherwise go unnoticed.
This accuracy supports physicians in creating personalized treatment plans, improving outcomes, and minimizing unnecessary interventions.
Relevant Guidelines
Accurate, reliable, evidence-based women’s health diagnostics
World Health Organization
- Provides global standards for reproductive, metabolic, and hormonal health.
- Recommends early screening for anemia, thyroid disorders, diabetes, and cancers.
- Emphasizes quality assurance and culturally appropriate care.
- Supports evidence-based diagnostic protocols.
Clinical and Laboratory Standards Institute
- Sets technical standards for LCMS testing.
- Focuses on validation, accuracy, and reproducibility.
- Guides sample collection, storage, and preparation.
- Defines quality control and reporting standards.
National Institute for Health and Care Excellence
- Offers evidence-based diagnostic pathways for women’s health in the UK.
- Guides lab testing, interpretation, and follow-up care.
- Promotes cost-effective and clinically effective strategies.
- Regularly updated to reflect latest research.
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About Us
Metropolis Healthcare is one of India’s leading diagnostics companies, with 45 years of experience built on scientific expertise, quality and trust. We serve millions of patients through a growing network supported by advanced laboratory infrastructure, technology and a patient-first approach. Our comprehensive portfolio includes 4,500+ tests and profiles across routine, specialised and super-specialised diagnostics, spanning pathology, molecular diagnostics, genomics, cytogenetics, oncology, neurology, nephrology, women and child health, preventive healthcare and wellness.
With 210+ clinical laboratories and a service network of 5,000+ touchpoints reaching more than 750 towns in India, we are focused on making trusted diagnostic services more accessible while maintaining rigorous quality standards. By combining scientific excellence, advanced technology and human expertise, we deliver accurate, reliable and relevant diagnostic insights that support better-informed healthcare decisions.