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NextGen Genecore Paradigm - PDL1 and HRD**
₹ 120000
NextGen Genecore Paradigm - PDL1 and HRD
₹ 120000 ₹ 120000

NextGen Genecore Paradigm - PDL1 and HRD

Sample Type 51+ booked in last 3 days

NextGen Genecore Paradigm - PDL1 and HRD** Price

₹ 120000

Brief Details

Preparation
Clinical history with a histopathology report is required.
Also Known As
Genecore Paradigm - PDL1 and HRD
Fasting
Not required
Reporting Time
After 25 days
Purpose
Actionable mutations in solid tumours, supports the identification of targeted therapy options, aids in guiding precision oncology treatment, and detect PDL1 expression in tumour tissues for immunotherapy eligibility.

What Is a NextGen GeneCore Paradigm – PDL1 and HRD? 

The NextGen GeneCore Paradigm – PDL1 and HRD is an advanced genetic test that combines two critical biomarker analyses using next-generation sequencing technology (NGS). This comprehensive diagnostic panel is performed on tumour tissue samples to provide your oncologist with detailed information about your cancer's characteristics. 

The test helps detect specific biological markers that guide treatment decisions for cancer patients, particularly identifying which modern treatments like immunotherapy or targeted therapy will be most effective for your individual case. 

What Does the NextGen GeneCore Paradigm – PDL1 and HRD Measure? 

The GeneCore Paradigm – PDL1 and HRD provides your oncologist with a detailed molecular profile of your cancer to enable personalised treatment decisions. The test measures: 

  • Programmed Death-Ligand 1 (PD-L1) Expression: Measures the amount of PD-L1 protein on cancer cells, which helps determine if immunotherapy treatments will be effective. 
  • Homologous Recombination Deficiency (HRD) Status: Checks if cancer cells have faulty DNA repair mechanisms, indicating vulnerability to PARP inhibitor treatments 
  • Actionable mutations: Identifies genetic changes in tumour cells that can be targeted with specific therapies. 
  • Treatment response predictors: Provides information to guide precision oncology treatment decisions. 

NextGen GeneCore Paradigm – PDL1 and HRD: Who Needs It and Why It's Done 

What Symptoms May Call for a NextGen GeneCore Paradigm – PDL1 and HRD? 

This test is not ordered based on specific symptoms but is recommended after a cancer diagnosis. The decision to order this test depends on your cancer type, stage, and characteristics rather than initial symptoms: 

  • Already diagnosed with solid tumours where targeted therapies are available 
  • Cancer that has spread or returned after initial treatment 
  • Need for personalised treatment planning beyond standard chemotherapy. 
  • Consideration for immunotherapy or PARP inhibitor treatments 

Who Should Get a NextGen GeneCore Paradigm – PDL1 and HRD? 

This test is recommended for patients with specific types of cancer where treatments targeting PD-L1 and HRD pathways have proven effective: 

  • Ovarian cancer patients: Particularly those with high-grade serous ovarian cancer 
  • Triple-negative breast cancer patients: Where targeted therapies may be beneficial 
  • Non-small cell lung cancer patients: To determine immunotherapy eligibility 
  • Pancreatic cancer patients: To identify treatment vulnerabilities 
  • Other solid tumours: As determined by your oncologist based on clinical evidence 

Why Is a NextGen GeneCore Paradigm – PDL1 and HRD Done? 

This test is performed to predict how your tumour will respond to specific treatments, allowing your doctor to select personalised therapy with the highest chance of success while avoiding ineffective treatments and their side effects. 

Importance of a NextGen GeneCore Paradigm – PDL1 and HRD 

The GeneCore Paradigm – PDL1 and HRD test marks a turning point in modern precision cancer care. By identifying specific vulnerabilities in your tumour, such as high PD-L1 expression or HRD status, doctors can prescribe powerful targeted therapies or immunotherapies that are most likely to work for your individual case. 

The test significantly improves treatment outcomes, as patients receiving biomarker-matched therapy often experience better responses and improved survival rates compared to standard treatments. It also helps avoid unnecessary toxicity and costs by ensuring expensive, potent drugs are given only to patients who will benefit most, protecting others from potential side effects, health risks, and financial burdens. 

NextGen GeneCore Paradigm – PDL1 and HRD Booking & Reports – Metropolis Healthcare India 

How to Book a NextGen GeneCore Paradigm – PDL1 and HRD? 

  1. Simple Online Booking 
    Booking can be done through the Metropolis Healthcare App or website. Select the 'NextGen GeneCore Paradigm – PDL1 and HRD', choose a convenient time slot, and visit the nearest Metropolis Lab. 
     
  2. Sample Tracking Updates 
    Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. 
     
  3. Accurate Laboratory Testing 
    Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 
     
  4. Quick & Easy Reports 
    Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is Home Sample Collection for NextGen GeneCore Paradigm – PDL1 and HRD Available Near You? 

No, home sample collection is not applicable for the GeneCore Paradigm – PDL1 and HRD. This test requires tumour tissue samples that are typically collected during medical procedures, like biopsies or surgeries, which must be performed in clinical settings. However, Metropolis Healthcare provides convenient sample processing services through our extensive network of over 10,000+ touchpoints across India. 

How Long Does It Take to Get a NextGen GeneCore Paradigm – PDL1 and HRD Report? 

Reports are usually available within 25 days once the sample reaches the pathology lab. 

Note: Reporting time may vary depending on your location. 

Where Can I See or Get NextGen GeneCore Paradigm – PDL1 and HRD Results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting NextGen GeneCore Paradigm – PDL1 and HRD Results 

What Your NextGen GeneCore Paradigm – PDL1 and HRD Results May Indicate 

The following table guides understanding of your test results, though your oncologist will interpret these findings in the context of your specific cancer type and overall health: 

Parameter 

Result Type 

Positive/High Results 

Negative/Low Results 

PD-L1 Expression 

Percentage score (TPS) 

High expression suggests a good response to immunotherapy treatments. 

Low expression indicates immunotherapy may be less effective. 

HRD Status 

Positive/Negative 

HRD-positive indicates vulnerability to PARP inhibitor treatments. 

HRD-negative suggests DNA repair pathways are functioning normally. 

553 Actionable Mutations 

Present/Absent 

Specific mutations were detected that can be targeted with available therapies. 

No targetable mutations identified with current treatments. 

Conditions That May Affect NextGen GeneCore Paradigm – PDL1 and HRD Accuracy 

Several factors can influence the accuracy of your test results and should be discussed with your healthcare team: 

  • Tissue sample quality: Inadequate or degraded tissue samples may affect test reliability. 
  • Tumour heterogeneity: Different areas of the same tumour may have varying characteristics. 
  • Previous treatments: Prior chemotherapy or radiation may alter tumour biology. 
  • Sample handling and storage: Improper tissue preservation can impact genetic analysis. 
  • Technical limitations: Some genetic alterations may be below detection thresholds. 
  • Contamination: Normal tissue contamination can dilute tumour-specific signals. 

How Is a NextGen GeneCore Paradigm – PDL1 and HRD Done? 

The test involves several carefully coordinated steps to ensure accurate analysis of your tumour tissue: 

  • Tissue collection: A biopsy or surgical sample is obtained by your doctor during a medical procedure. 
  • Sample preparation: The tissue is preserved in formalin and embedded in paraffin wax blocks. 
  • Quality assessment: Laboratory specialists evaluate tissue quality and tumour content. 
  • DNA/RNA extraction: Genetic material is carefully extracted from the tumour cells. 
  • Next-generation sequencing: Advanced sequencing technology analyses multiple genes simultaneously. 
  • Bioinformatics analysis: Sophisticated computer algorithms interpret the genetic data. 
  • Report generation: Results are compiled into a comprehensive report for your oncologist. 

How Should You Prepare for a NextGen GeneCore Paradigm – PDL1 and HRD? 

Preparation for this test focuses on the tissue collection procedure rather than the laboratory analysis itself: 

  • No fasting required: Your eating and drinking habits do not affect the tissue analysis. 
  • Continue medications: Unless specifically instructed otherwise by your doctor for the biopsy procedure. 
  • Provide a complete medical history: Share all relevant information about your cancer diagnosis and treatments. 
  • Bring histopathology reports: Previous tissue analysis reports help guide the testing process. 
  • Follow biopsy instructions: If tissue collection is needed, follow your doctor's specific preparation guidelines. 

Diseases that the NextGen GeneCore Paradigm – PDL1 and HRD Can Help Detect 

This test helps characterise various solid tumours and guide treatment decisions for several cancer types: 

  • Ovarian cancer: Particularly high-grade serous ovarian carcinoma 
  • Breast cancer: Including triple-negative and BRCA-associated cancers 
  • Lung cancer: Non-small cell lung cancer requiring immunotherapy assessment 

NextGen GeneCore Paradigm – PDL1 and HRD/Packages that You Can Book With Metropolis Healthcare 

The following table shows related tests that complement comprehensive cancer care and treatment planning: 

Test/Package Name 

Purpose/Highlights 

Tumour Mutation Burden NGS 

Measures overall genetic changes in tumours to predict immunotherapy response 

PDL1 (SP263) IHC 

An immunohistochemistry test specifically for PD-L1 protein expression 

Microsatellite Instability (MSI)/HNPCC/Lynch Syndrome PCR 

Detects DNA mismatch repair deficiency for targeted treatment options 

BRCA1/2 Targeted Mutation Analysis 

Identifies hereditary breast and ovarian cancer gene mutations 

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Ratings & Reviews

We're satisfying our customers every day since 1980.

Morning given the samples in Ayanavaram branch got the report by 12.30pm it's fast and efficient delivery by mail and want to tell about the staff they are very professional and friendly definitely I will recommend my friends and family to metropolis labs

Prabhu Gopalakrishnan. 5

The Home Service was excellent. Medical Technician took samples at 7:00am and returned at 9:30 after breakfast to take further samples. The results were sent by email at 6pm. The whole experience was excellent, professional and well organised. Will certainly recommend the home service for convenience

Chris Bessell 5

Excellent service - I was able to request services late at night (9pm) and the technician was at my door at 7:30am the next morning. The services were highly affordable and convenient. I live in the US and the US could learn a lot from Metropolis!!!

Sharmila Vaishnav. 5

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

Very good staff, excellent execution of samples, timely results even before promised time. professional and well organised. Will certainly recommend the home service for convenience

Ishwarakrishnan. 4

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Why Metropolis Healthcare?

Metropolis has been present for over 40 years in the market.

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

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Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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