17p Deletion by FISH, p53 (MM, CLL)
17p Deletion p53 (MM, CLL), Heparin Blood Price
17p Deletion by FISH Test Overview
The 17p Deletion by FISH test is a diagnostic tool used to identify specific chromosomal abnormality: the deletion of the short arm of chromosome 17 (17p). This region includes the TP53 gene, essential for tumour suppression. The FISH 17p deletion test uses fluorescent probes that attach to DNA sequences on chromosome 17. These can be seen under a microscope. If the 17p deletion is present, either no signal or only one signal will appear, instead of the usual two signals for this chromosome region.
This FISH 17p Deletion test is crucial for diagnosing and managing various blood cancers, including Chronic Lymphocytic Leukaemia (CLL), Acute Myeloid Leukaemia (AML), Myelodysplastic Syndromes (MDS), and plasma cell disorders. A 17p deletion often indicates a tougher disease course and a potential resistance to standard chemotherapy.
A 17p Deletion by FISH test looks for a missing piece (deletion) on the short arm (p) of chromosome 17, particularly focusing on the p53 gene. This test is commonly done in patients with Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) because this deletion disrupts the p53 gene, which normally helps suppress tumors.
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