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Sompraz D 40 is a prescription medicine used mainly to manage gastro-oesophageal reflux disease, commonly called GERD or acid reflux. It combines an acid-reducing medicine with a medicine that improves movement in the upper digestive tract.
Although many people search for the term Sompraz D 40 tablet, this medicine is usually available as a sustained-release capsule. You should check the product label and take only the formulation prescribed for you.
Do not use Sompraz D 40 for frequent acidity without medical advice. Persistent gastrointestinal symptoms may need proper evaluation to identify their cause.
What Is Sompraz D 40?
Sompraz D 40 is a combination of:
- Esomeprazole 40 mg
- Domperidone 30 mg in a sustained-release form
Esomeprazole belongs to a group of medicines called proton pump inhibitors, or PPIs. It reduces the amount of acid produced by your stomach.
Domperidone is a prokinetic and anti-sickness medicine. It helps food move through the upper digestive tract and may reduce nausea, vomiting and uncomfortable fullness in selected patients.
The sustained-release formulation releases domperidone gradually. You must swallow the capsule whole so that the medicine works as intended.
How Sompraz D 40 Works
The two ingredients act in different ways.
Esomeprazole blocks acid-producing pumps in the stomach lining. This reduces the amount of acid that can flow back into your food pipe. It also creates a less acidic environment that allows irritated tissue to heal.
Domperidone blocks certain dopamine receptors in the digestive system. This may improve stomach movement and help food pass into the intestine more efficiently. It can also help control nausea and vomiting.
Together, these actions may relieve acid reflux when it occurs with symptoms such as nausea, regurgitation or post-meal fullness. However, the combination is not suitable for every type of acidity or gastrointestinal problem.
Sompraz D 40 Uses
The main Sompraz D 40 uses relate to GERD and associated upper digestive symptoms.
A doctor may prescribe it for:
- Frequent heartburn caused by acid reflux
- Acid regurgitation
- GERD associated with nausea
- Inflammation of the food pipe caused by acid
- Post-meal fullness associated with slow stomach movement
- Acid-related discomfort when a combination medicine is considered appropriate
The exact reason for your prescription should be confirmed with your doctor.
Acid Reflux And GERD
GERD develops when stomach contents repeatedly travel back into your oesophagus. This can cause heartburn, a sour taste, regurgitation, throat irritation or discomfort behind your breastbone.
Sompraz D 40 reduces stomach acid. The domperidone component may also support stomach emptying in selected people.
You may notice symptom relief within a few days, but healing from acid-related inflammation can take longer. Continue the treatment for the duration prescribed.
Seek medical assessment if you have difficulty swallowing, repeated vomiting, unexplained weight loss, black stools or blood in your vomit. These symptoms should not be treated as routine acidity.
Peptic Ulcers
Esomeprazole is used in several treatment plans for peptic ulcers. It may help an ulcer heal by reducing stomach acid.
However, Sompraz D 40 is not automatically the right treatment for every peptic ulcer. The domperidone component may not be necessary.
Some peptic ulcers are caused by an infection called Helicobacter pylori. In these cases, acid suppression alone cannot clear the infection. Your doctor may prescribe antibiotics with a PPI after appropriate testing.
Other peptic ulcers are linked to regular use of pain-relieving medicines known as non-steroidal anti-inflammatory drugs. Treatment depends on whether you need to continue these medicines and your risk of bleeding.
Zollinger-Ellison Syndrome
Zollinger-Ellison syndrome is a rare condition in which one or more tumours cause excessive stomach acid production. It can lead to repeated ulcers, abdominal pain and severe diarrhoea.
Esomeprazole may be used to control acid production in Zollinger-Ellison syndrome. However, the required dose is often different from the dose used for ordinary reflux.
Long-term domperidone is not a routine part of treatment for Zollinger-Ellison syndrome. You should take the Sompraz D 40 combination for this condition only when a specialist has specifically prescribed it.
Benefits Of Sompraz D 40
When it is prescribed for an appropriate condition, Sompraz D 40 may:
- Reduce excessive stomach acid
- Relieve heartburn and acid regurgitation
- Support the healing of acid-related oesophageal inflammation
- Reduce nausea and vomiting in selected patients
- Improve uncomfortable post-meal fullness
- Provide the convenience of two medicines in one capsule
The medicine controls symptoms but does not remove every possible cause of acid reflux. Healthy eating habits, weight management and other lifestyle changes may still be needed.
Sompraz D 40 Dosage And Timing
Your dosage and treatment duration depend on your symptoms, medical history and response to treatment.
Aspect | General Guidance |
Usual timing | Take it 30 to 60 minutes before a meal, usually before breakfast |
Food instructions | Take it on an empty stomach |
Method | Swallow the capsule whole with water |
Crushing or chewing | Do not crush, chew or break it |
Frequency | It is often prescribed once daily, but your prescription may differ |
Treatment duration | Use it for the period advised by your doctor |
Missed dose | Take it when you remember unless your next dose is nearly due |
Double dose | Do not take two capsules together |
Taking the capsule before a meal allows esomeprazole to act when the acid-producing pumps become active.
Sompraz D 40 contains 30 mg of domperidone. Do not take extra doses unless your doctor has specifically instructed you to do so.
Side Effects Of Sompraz D 40
Most side effects are mild and temporary. However, tell your doctor if they persist or interfere with your daily activities.
Common side effects include:
- Dry mouth
- Headache
- Diarrhoea
- Stomach pain
- Flatulence
- Nausea
- Dizziness
- Constipation
Drink enough fluids if you develop mild diarrhoea. Seek medical advice if it becomes persistent, severe, watery or bloody.
Domperidone can sometimes increase the hormone prolactin. This may cause breast tenderness, unexpected milk secretion or menstrual changes. Speak to your doctor if you notice these effects.
Serious Side Effects
Stop taking the medicine and seek prompt medical care if you experience:
- A fast or irregular heartbeat
- Severe palpitations
- Fainting or feeling close to fainting
- Chest pain
- Difficulty breathing
- Swelling of your face, lips or throat
- A severe skin rash
- Vomiting blood
- Black or tar-like stools
- Severe or persistent abdominal pain
These effects are uncommon but require timely assessment.
Precautions And Warnings
Tell your doctor before taking Sompraz D 40 if you:
- Have an irregular heartbeat or another heart condition
- Have a history of prolonged QT interval
- Have low potassium or magnesium levels
- Have moderate or severe liver disease
- Have significant kidney disease
- Have a blockage, bleeding or tear in your digestive tract
- Have a tumour of the pituitary gland
- Are older than 60 years
- Are pregnant or planning a pregnancy
- Are breastfeeding
- Have been taking another acid-suppressing medicine
- Are taking several prescription medicines
Domperidone has been linked to a small increase in the risk of serious abnormal heart rhythms. The risk may be greater in older adults, people with heart disease, those with electrolyte abnormalities and those taking interacting medicines.
Use the medicine at the prescribed dose for the shortest duration appropriate for your condition. Do not continue it indefinitely because your acidity returns when you stop.
Long-Term Use And Health Monitoring
Some people need longer treatment with esomeprazole because of severe GERD or another diagnosed condition. Long-term treatment should be reviewed regularly.
Prolonged PPI use may be associated with:
- Low magnesium levels
- Reduced vitamin B12 absorption
- A higher risk of certain gastrointestinal infections
- A small increase in fracture risk in susceptible people
- Kidney inflammation
- Benign stomach gland polyps
These risks do not mean you should stop a necessary medicine. Your doctor will consider whether the benefits remain greater than the risks.
Blood tests may be recommended if you use a PPI for an extended period, particularly if you have symptoms of a nutrient deficiency or take medicines that affect electrolyte levels.
Sompraz D 40 Drug Interactions
Sompraz D 40 can interact with medicines that affect heart rhythm, domperidone metabolism or stomach acid.
Tell your doctor if you take:
- Medicines for an irregular heartbeat
- Certain antibiotics, including macrolide antibiotics
- Azole antifungal medicines
- Certain antidepressants or antipsychotic medicines
- HIV medicines
- Clopidogrel
- Warfarin or another blood thinner
- Digoxin
- Methotrexate
- Phenytoin
- Diazepam
- Rifampicin
- St John's wort
- Diuretics that may lower potassium or magnesium
Do not start a new medicine or supplement without checking with your doctor or pharmacist.
Lifestyle Measures That May Help
Medicine works best when you also address factors that trigger acid reflux.
You can:
- Eat smaller meals
- Avoid lying down for at least three hours after eating
- Identify foods that trigger your symptoms
- Limit very fatty or spicy meals if they worsen your reflux
- Reduce alcohol and caffeine if they are triggers
- Stop smoking
- Maintain a healthy weight
- Raise the head of your bed if symptoms occur at night
- Avoid tight clothing around your abdomen
You do not need to avoid every food commonly linked to acidity. Focus on the items that repeatedly trigger your symptoms.
Frequently Asked Questions
Should Sompraz D 40 Be Taken Before Or After Meals?
Take Sompraz D 40 on an empty stomach, usually 30 to 60 minutes before breakfast. Follow the timing printed on your prescription if it differs.
How Long Can You Take Sompraz D 40 Safely?
The safe duration depends on why it was prescribed and your health risks. Because the medicine contains domperidone, it should be used for the shortest period considered necessary.
Do not repeat or extend the course without a medical review. Long-term PPI treatment may be appropriate for some conditions, but the need for domperidone should be assessed separately.
Can Sompraz D 40 Cause Heart Palpitations?
Yes. Domperidone can rarely affect the electrical rhythm of your heart.
Seek prompt medical care if you experience strong palpitations, an irregular heartbeat, severe dizziness or fainting. Your doctor may review your medicines, electrolyte levels and electrocardiogram.
Does Sompraz D 40 Cause Diarrhoea?
Diarrhoea is a recognised side effect of esomeprazole. It is usually mild.
Contact your doctor if you have severe, persistent, watery or bloody diarrhoea, particularly when accompanied by fever or abdominal pain.
Can Sompraz D 40 Be Stopped Suddenly?
A short prescribed course can usually be stopped when your doctor instructs you to stop. After prolonged PPI treatment, some people experience temporary rebound acidity when the medicine is discontinued.
Your doctor may recommend stopping it directly, reducing the dose or changing to another treatment. Do not change a long-term treatment plan on your own.
Can You Take Sompraz D 40 For Everyday Acidity?
Do not take it regularly without medical advice. Frequent acidity may be related to GERD, an ulcer, medicine use or another gastrointestinal condition.
An evaluation can help you receive the right treatment rather than repeatedly suppressing the symptoms.
Conclusion
Sompraz D 40 combines esomeprazole with sustained-release domperidone. It is mainly prescribed for GERD when acid reflux occurs with symptoms that may benefit from improved stomach movement or nausea control.
Take it before food, swallow the capsule whole and follow the prescribed duration. Seek medical care if you develop severe diarrhoea, fainting, palpitations, bleeding symptoms or difficulty swallowing.
Persistent or recurring digestive symptoms may require tests such as a complete blood count, liver and kidney function tests, electrolyte tests or testing for Helicobacter pylori. The appropriate tests depend on your symptoms and treatment history.
Metropolis Healthcare supports timely diagnosis and preventive health monitoring through more than 4,000 tests, full body checkups and speciality testing. You can book through the website, app, call or WhatsApp. Home sample collection is available through a strong network of 10,000 touchpoints, with accurate results and convenient report access.
References
- CIMS India. Sompraz D 40 Capsule SR: product information. Sun Pharmaceutical Industries Ltd. Accessed 20 July 2026.
- European Medicines Agency. Domperidone-containing medicines: Article 31 referral assessment and restrictions on use. EMA/152501/2014. 2014.
- National Library of Medicine. Esomeprazole magnesium delayed-release capsules: prescribing information. DailyMed. Accessed 20 July 2026.
- Targownik LE, Fisher DA, Saini SD. AGA Clinical Practice Update on de-prescribing of proton pump inhibitors: expert review. Gastroenterology. 2022;162(4):1334-1342. PMID: 35183361.
- National Institute for Health and Care Excellence. Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. Clinical guideline CG184. 2014, updated 2019.
