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What is LCMS?

LCMS (Liquid Chromatography–Mass Spectrometry) is an advanced analytical technique combining liquid chromatography separation with mass spectrometry detection. It provides precise identification and quantification of compounds in complex biological samples.

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Uses of LCMS

LCMS delivers precise analysis of complex samples, essential for modern diagnostics and research.

Detecting Vitamin

Detecting Vitamin and Mineral Deficiencies

LCMS provides precise detection of essential nutrients like Vitamin D, B12, and trace elements. This ensures early diagnosis of deficiencies affecting energy, immunity, and bone health.

Drug and Metabolite Monitoring

Drug and Metabolite Monitoring

Tracks therapeutic drug levels and metabolites in the bloodstream for effective dosage and toxicity prevention. Often used in post-treatment monitoring or chronic condition management.

Biomarkers Research

Research on Biomarkers for Women’s Health

Supports advanced research by identifying and quantifying biomarkers linked to conditions such as PCOS, osteoporosis, and cardiovascular risk in women.

Methodology

Liquid Chromatography–Mass Spectrometry (LCMS) is a two-step analytical technique that combines separation and detection for highly accurate results. In the first stage, liquid chromatography separates complex biological samples into individual components based on their chemical properties. These isolated compounds are then analyzed by mass spectrometry, which identifies and quantifies them with exceptional precision.

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Sample Preparation

Biological samples (e.g., blood, serum, urine) are collected and processed to remove impurities.

Proper preparation ensures reliable and reproducible results.

Liquid Chromatography (LC) Separation

LC separates compounds based on chemical properties like polarity or size.

This step isolates individual components from complex mixtures.

Mass Spectrometry (MS) Detection

MS measures the mass-to-charge ratio of the separated compounds.

Provides molecular identification and quantification with extreme sensitivity.

Data Analysis & Reporting

Advanced software interprets the data, generating clear visualizations and reports.

Supports clinical decision-making with accurate, actionable insights.

Tests Performed

Essential tests for key hormones, vitamins, and minerals to guide accurate health insights.

Hormone Panels

Hormone Panels

Evaluates key reproductive hormones to detect imbalances affecting fertility, menstrual cycles, and overall women’s health.

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Vitamin D & B12 Testing

Vitamin D & B12 Testing

Measures essential vitamins crucial for bone strength, energy levels, and nerve function to prevent deficiencies.

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Metabolite Profiling for PCOS

Metabolite Profiling for PCOS

Analyzes metabolic markers to identify hormonal and insulin-related irregularities linked to polycystic ovary syndrome.

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Trace Elements Testing

Trace Elements (Iron, Zinc)

Assesses vital minerals that support immunity, oxygen transport, and cellular health for overall body function.

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Clinical Rationale

LCMS plays a vital role in delivering precise and reliable diagnostics for women’s health. By combining high sensitivity with robust specificity, it enables early detection of hormonal imbalances, nutrient deficiencies, and metabolic disorders that may otherwise go unnoticed.

This accuracy supports physicians in creating personalized treatment plans, improving outcomes, and minimizing unnecessary interventions.

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Relevant Guidelines

Accurate, reliable, evidence-based women’s health diagnostics

WHO Logo

World Health Organization

  • Provides global standards for reproductive, metabolic, and hormonal health.
  • Recommends early screening for anemia, thyroid disorders, diabetes, and cancers.
  • Emphasizes quality assurance and culturally appropriate care.
  • Supports evidence-based diagnostic protocols.
CLSI Logo

Clinical and Laboratory Standards Institute

  • Sets technical standards for LCMS testing.
  • Focuses on validation, accuracy, and reproducibility.
  • Guides sample collection, storage, and preparation.
  • Defines quality control and reporting standards.
NICE Logo

National Institute for Health and Care Excellence

  • Offers evidence-based diagnostic pathways for women’s health in the UK.
  • Guides lab testing, interpretation, and follow-up care.
  • Promotes cost-effective and clinically effective strategies.
  • Regularly updated to reflect latest research.

Frequently asked questions

Find quick answers to the most common questions about health tests, bookings, and reports.

Regular exercise, a balanced diet, avoiding smoking, maintaining a healthy weight, and managing stress all help reduce heart disease risk.

Common signs include irritability, trouble sleeping, headaches, difficulty concentrating, and muscle tension.

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About Us

Metropolis Healthcare is a leading diagnostic service provider in India. We are a team of dedicated professionals committed to ensuring you and your family receive the most accurate and timely healthcare solutions. We believe in making health care accessible, affordable and evidence-based. Our expert panel are equipped with the latest technology and manned by a certified team of over 4000+ technicians.

In diagnostic services, we have more than three decades of experience servicing diverse stakeholders health advantage packages for men, women and seniors, genetic fitness & corporation in over 650+ tests like Oncology, Neurology, Gynaecology, Haematology, and many more. Our diagnostic services are located in leading doctors and clinics and serve over 15+ cities in India.

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